Chimeric antigen receptor T-cell immunotherapy for glioblastoma: practical insights for neurosurgeons

Neurosurgical Focus
Bryan D ChoiMarcela V Maus

Abstract

The prognosis for glioblastoma (GBM) remains exceedingly poor despite state-of-the-art multimodal therapy. Immunotherapy, particularly with cytotoxic T cells, represents a promising alternative. Perhaps the most prominent T-cell technology is the chimeric antigen receptor (CAR), which in 2017 received accelerated approval from the Food and Drug Administration for the treatment of hematological malignancies. Several CARs for GBM have been recently tested in clinical trials with exciting results. The authors review these clinical data and discuss areas of ongoing research.

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Citations

Jul 11, 2019·The Journal of Clinical Endocrinology and Metabolism·Siao Ting ChongJoanne Ngeow
Mar 7, 2020·Science Translational Medicine·Dongrui WangChristine E Brown
Jul 25, 2019·Nature Biotechnology·Bryan D ChoiMarcela V Maus
Nov 18, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bryan D ChoiJohn H Sampson
Mar 7, 2021·International Journal of Molecular Sciences·Evita AthanasiouAthanassios Tsakris
Apr 4, 2021·Brain Sciences·Alice Giotta Lucifero, Sabino Luzzi

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Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT02209376
NCT01109095
NCT00730613
NCT02208362
NCT01082926

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