Chimeric antigen receptor T cells for sustained remissions in leukemia

The New England Journal of Medicine
Shannon L MaudeStephan A Grupp

Abstract

Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor-modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce remission in patients with refractory disease. We infused autologous T cells transduced with a CD19-directed chimeric antigen receptor (CTL019) lentiviral vector in patients with relapsed or refractory ALL at doses of 0.76×10(6) to 20.6×10(6) CTL019 cells per kilogram of body weight. Patients were monitored for a response, toxic effects, and the expansion and persistence of circulating CTL019 T cells. A total of 30 children and adults received CTL019. Complete remission was achieved in 27 patients (90%), including 2 patients with blinatumomab-refractory disease and 15 who had undergone stem-cell transplantation. CTL019 cells proliferated in vivo and were detectable in the blood, bone marrow, and cerebrospinal fluid of patients who had a response. Sustained remission was achieved with a 6-month event-free survival rate of 67% (95% confidence interval [CI], 51 to 88) and an overall survival rate of 78% (95% CI, 65 to 95). At 6 months, the probability that a patient would have persistence of CT...Continue Reading

References

May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stacey L BergChildren's Oncology Group
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cor LamersEgbert Oosterwijk
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael H KershawPatrick Hwu
Apr 23, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Michael C MiloneCarl H June
May 5, 2011·The Journal of Clinical Investigation·Barbara SavoldoGianpietro Dotti
Aug 13, 2011·The New England Journal of Medicine·David L PorterCarl H June
Dec 23, 2011·Current Opinion in Pediatrics·Kimberly Risma, Michael B Jordan
Nov 22, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan M O'BrienHagop M Kantarjian
Dec 18, 2012·Blood·Stephen J Forman, J M Rowe
Mar 27, 2013·The New England Journal of Medicine·Stephan A GruppCarl H June
May 4, 2013·The Lancet Oncology·Deepa Bhojwani, Ching-Hon Pui
May 7, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Li Mei PoonPartow Kebriaei
Feb 21, 2014·Science Translational Medicine·Marco L DavilaRenier J Brentjens
Mar 29, 2014·The Cancer Journal·Shannon L MaudeStephan A Grupp

Citations

Oct 29, 2014·Nature Reviews. Clinical Oncology·Lisa Hutchinson
Dec 3, 2014·Best Practice & Research. Clinical Haematology·Stephan A Grupp
Dec 10, 2014·Nature Biotechnology·Chris Morrison
Dec 5, 2014·Future Oncology·Sameer A Parikh, Mark R Litzow
Nov 18, 2015·Immunological Investigations·Thinle ChodonKunle Odunsi
Oct 17, 2015·Immunopharmacology and Immunotoxicology·Doraid AlrifaiJohn Maher
Feb 18, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Letícia BaggioDean A Lee
Jul 21, 2015·Expert Opinion on Therapeutic Targets·Yangyang WangGianpietro Dotti
Sep 25, 2015·Expert Review of Anticancer Therapy·Rajasekharan Somasundaram, Meenhard Herlyn
Jan 19, 2016·Expert Review of Hematology·Armin Rashidi, Roland B Walter
Nov 20, 2015·Expert Review of Hematology·Benjamin KasendaIan Chau
May 8, 2015·Expert Review of Hematology·Tobias Riet, Hinrich Abken
Jun 18, 2015·Expert Review of Clinical Immunology·Randy Q CronAngelo Ravelli
Oct 24, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ibrahim AldossVinod Pullarkat
Dec 15, 2015·Expert Review of Anticancer Therapy·N J Morley, D Marks
Feb 15, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Hakan GokerYahya Buyukasik
May 20, 2015·Expert Opinion on Biological Therapy·M Chmielewski, Hinrich Abken
May 20, 2015·Expert Opinion on Biological Therapy·Britny RogalaMeir Wetzler
Feb 11, 2015·Expert Opinion on Biological Therapy·Diana C G BouhassiraMarco L Davila
Apr 4, 2015·Science·Steven A Rosenberg, Nicholas P Restifo
Feb 24, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Miguel-Angel PeralesPhilippe Armand
Feb 11, 2016·Immunotherapy·Wen-Long Zhang
Apr 5, 2016·Seminars in Oncology·Joseph A FraiettaMarcela V Maus
Feb 20, 2016·Archives of Pharmacal Research·Mi-Gyeong KimYu-Kyoung Oh
Feb 11, 2016·Seminars in Immunology·Lidia RobertSiwen Hu-Lieskovan
Jan 26, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Monzr M Al MalkiStefan O Ciurea
Jan 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jennifer S Y MaYu Cao
Jan 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·David T RodgersTravis S Young
Feb 2, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lawrence G LumVoravit Ratanatharathorn
Feb 2, 2016·Veterinary Immunology and Immunopathology·Matthew J AthertonBrian D Lichty
Mar 22, 2016·Journal of Immunology Research·Yelei GuoWeidong Han
Feb 24, 2016·Nature Biotechnology·Lingfeng LiuStanley Riddell
Jan 23, 2016·British Journal of Haematology·Djordje AtanackovicTim Luetkens
Feb 18, 2016·Journal for Immunotherapy of Cancer·Michael Kalos
Nov 22, 2015·Science China. Life Sciences·Yang LiXi Wang
Nov 18, 2015·American Journal of Hematology·Noelle V Frey, David L Porter
Sep 4, 2015·Annual Review of Medicine·Carlos A RamosMalcolm K Brenner
Jan 19, 2016·Critical Reviews in Oncology/hematology·Omar Al UstwaniMeir Wetzler
Jan 23, 2016·Seminars in Immunology·Claudia GeldresGianpietro Dotti
Dec 1, 2015·Future Oncology·Craig ErkerMichael J Burke
Jan 11, 2016·Journal of Internal Medicine·S MuenstS Hoeller
Jan 8, 2016·Science Translational Medicine·Nathan SinghD M Barrett
Jan 7, 2016·Nature Medicine·Christopher A KlebanoffNicholas P Restifo
Oct 28, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mark J OsbornBruce R Blazar
Mar 5, 2016·Oncoimmunology·Nathan SinghStephan A Grupp
Oct 21, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Miguel-Angel PeralesPhilippe Armand
Sep 8, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Elad JacobyHeather J Symons
Jan 24, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C Y CheahMichael L Wang
Dec 30, 2015·Seminars in Immunology·Yun JiLuca Gattinoni
Nov 4, 2015·Nature Reviews. Clinical Oncology·Connie Lee BatleviAnas Younes
Jan 17, 2016·European Journal of Immunology·Alfonso R Sanchez-PauleteIgnacio Melero
Nov 14, 2015·Molecular Oncology·Lynsey M Whilding, John Maher
Nov 10, 2015·Molecular Oncology·Terhi Karpanen, Johanna Olweus
Mar 11, 2016·Current Opinion in Immunology·Eugene A ZhukovskyMarcela V Maus
Sep 8, 2015·Current Opinion in Pharmacology·Hans J StaussHinrich Abken
Feb 24, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gabriel N MannisAaron C Logan
Oct 7, 2015·Trends in Immunology·Yvonne Y Chen
Jul 29, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Daisuke Tomizawa
Mar 16, 2016·Bulletin du cancer·Wolf Hervé Fridman
Mar 16, 2016·Seminars in Immunology·Dirk H BuschStanley Riddell
Mar 12, 2016·Nature Reviews. Drug Discovery·Axel Hoos
Sep 22, 2015·Pharmacology & Therapeutics·Johan M van RooijenElisabeth G E de Vries
Sep 10, 2015·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Brigitte AnlikerMatthias Schweizer
Aug 1, 2015·Blood·David Marc Davies, John Maher
Mar 22, 2016·The Journal of Clinical Investigation·Katherine G MacDonaldMegan K Levings
Mar 22, 2016·British Journal of Haematology·Lisa Giulino-Roth, Stanton Goldman
Nov 21, 2015·Oncoimmunology·Marcela V Maus
Oct 16, 2015·The New England Journal of Medicine·Stephen P Hunger, Charles G Mullighan
Mar 25, 2016·British Journal of Haematology·Bruce ShiramizuWolfram Klapper
Jul 24, 2015·European Journal of Immunology·Chiara Bonini, Anna Mondino
Apr 14, 2016·Transfusion Medicine Reviews·Andrew FesnakMarcela V Maus
Nov 28, 2015·Seminars in Immunology·Paul A BeavisPhillip K Darcy
Sep 15, 2016·Molecular Therapy Oncolytics·Ruslan Novosiadly, Michael Kalos
Apr 12, 2016·Frontiers in Immunology·Ivan Borrello, Kimberly A Noonan
Mar 16, 2016·Nature Reviews. Clinical Oncology·Danny N KhalilJedd D Wolchok
Mar 24, 2016·Nature Reviews. Clinical Oncology·Hollie J JacksonRenier J Brentjens
Sep 19, 2015·Investigational New Drugs·Jason B KaplanFrancis J Giles
Apr 7, 2015·Cell Stem Cell·Maria ThemeliMichel Sadelain
Jun 19, 2015·British Journal of Haematology·Andrew G EvansJane L Liesveld
Oct 6, 2015·Trends in Pharmacological Sciences·Takashi AngataMatthew S Macauley
Sep 30, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Natalie M MountJohan Hyllner
Apr 24, 2015·Science Translational Medicine·Garret A FitzGerald
Oct 10, 2015·Oncoimmunology·Fernando ArandaLorenzo Galluzzi
Sep 4, 2015·Journal of Molecular Biology·Viktor Haellman, Martin Fussenegger
Apr 7, 2016·Leukemia & Lymphoma·Maria-Elisabeth Goebeler, Ralf C Bargou
Mar 25, 2016·Expert Review of Hematology·Elena MainoRenato Bassan
Jul 11, 2015·Human Molecular Genetics·Teresa ManzoCliona M Rooney
Jul 1, 2015·American Journal of Surgery·Roberto E Kusminsky
Apr 17, 2015·Blood·Yves ChalandonGroup for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)
Apr 9, 2016·Oncoimmunology·David C BinderDerek A Wainwright
Sep 10, 2015·The New England Journal of Medicine·Alfred L GarfallEdward A Stadtmauer
May 18, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·R Bryan Bell
May 20, 2015·Molecular Reproduction and Development·Xiao-Hang CheHong Zhu
Apr 12, 2016·British Journal of Haematology·Matthew J BarthMitchell S Cairo
Dec 17, 2014·Immunological Reviews·Michelle H Nelson, Chrystal M Paulos
Dec 17, 2014·Immunological Reviews·Martin Carroll
Dec 17, 2014·Immunological Reviews·Saar Gill, Carl H June
Mar 11, 2015·British Journal of Haematology·S GhorashianP J Amrolia
Mar 11, 2015·CA: a Cancer Journal for Clinicians·Peter C Adamson
Feb 14, 2015·Cancer·Weili SunAlan Wayne
Apr 3, 2015·Pediatric Blood & Cancer·Maya SuzukiNai-Kong V Cheung
Jul 8, 2015·European Journal of Immunology·Winfried PicklBarbara Bohle
Jul 15, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Piyanuch KongtimStefan O Ciurea
Sep 22, 2015·Frontiers in Immunology·Roberta ZappasodiMassimo Di Nicola
Aug 25, 2015·The Journal of Clinical Investigation·Terry J Fry, Peter D Aplan
Sep 1, 2015·Seminars in Oncology·Madhav V Dhodapkar, Kavita M Dhodapkar
Sep 1, 2015·Seminars in Oncology·Michael B Atkins, Mario Sznol
Sep 1, 2015·Seminars in Oncology·Steven A FeldmanSteven A Rosenberg
Apr 30, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L ApetohF Ghiringhelli
Jun 9, 2015·Current Opinion in Immunology·Haydn T Kissick, Martin G Sanda
Aug 25, 2015·BMC Medicine·Sathana DushyanthenSherene Loi
Aug 1, 2015·Human Gene Therapy·Gunilla EnbladAngelica Loskog
Aug 22, 2015·Blood·Hans J Stauss
Jan 17, 2015·Clinical Therapeutics·Ramez N Eskander, Krishnansu S Tewari
Jul 28, 2015·The Journal of Clinical Investigation·Cornelis J M MeliefSjoerd H van der Burg
Aug 13, 2015·Cancer Immunology, Immunotherapy : CII·Stefano UgelAndrea Facciabene
Jun 13, 2015·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M KroemerC Borg
Jan 18, 2015·Molecular Immunology·Connie P M DuongPhillip K Darcy
Jul 15, 2015·Trends in Immunology·Shivani Srivastava, Stanley Riddell
Jun 13, 2015·Immunotherapy·Yarne KlaverCor Lamers
Jun 11, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Julien ValtonLaurent Poirot
Jun 20, 2015·Trends in Biotechnology·Deboki Chakravarti, Wilson W Wong
Jun 13, 2015·Human Gene Therapy·Jennifer L GoriDavid Bumcrot
Mar 30, 2016·International Immunology·Matthew J Frigault, Marcela V Maus
Jun 3, 2015·Blood·Giada BianchiKenneth C Anderson
Mar 22, 2015·Cytotherapy·Jeannette CanyNina Shah
Jun 20, 2015·Frontiers in Immunology·Okjae LimEui-Cheol Shin
Jul 11, 2015·Oncoimmunology·Carter M SuryadevaraJohn H Sampson
Jun 5, 2015·Cancer Immunology, Immunotherapy : CII·Hiroaki Ikeda, Hiroshi Shiku
Mar 15, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Swati NaikRobert Krance
May 21, 2015·Journal of Translational Medicine·ZeNan L ChangYvonne Y Chen
Apr 19, 2016·Bone Marrow Transplantation·M Byrne, Bipin N Savani
May 2, 2015·Current Hematologic Malignancy Reports·Renato Bassan, Orietta Spinelli
May 23, 2015·Nature Reviews. Cancer·George J Weiner
Apr 22, 2015·Medical Microbiology and Immunology·J G Patrick Sissons, Mark R Wills
Jun 26, 2015·Pharmaceuticals·Kentaro MinagawaAntonio Di Stasi
Apr 11, 2015·Cancer Cell·Jacques F A P Miller, Michel Sadelain
Apr 11, 2015·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Victoria Hillerdal, Magnus Essand
Sep 15, 2016·Molecular Therapy Oncolytics·Challice L BonifantKevin J Curran
Feb 28, 2016·Immunology Letters·Swati SikariaMojtaba Akhtari
Feb 11, 2015·Current Opinion in Immunology·Evripidis LanitisGeorge Coukos
Mar 3, 2015·Current Opinion in Immunology·Thomas BlankensteinHans Schreiber
Jan 27, 2015·Current Opinion in Immunology·Michael C Jensen, Stanley Riddell
Mar 18, 2015·Der Internist·Nicola Gökbuget
Apr 26, 2016·The Journal of Clinical Investigation·Cameron J TurtleDavid Maloney
Mar 10, 2015·Bone Marrow Transplantation·N LendvaiH J Cho
Mar 3, 2015·Frontiers in Pharmacology·Wolfgang GlienkeUlrike Koehl
Feb 6, 2015·Nature Medicine·David Benjamin Turitz CoxFeng Zhang
Apr 5, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·K TaipaleAkseli Hemminki
May 18, 2016·Lancet·Jonathan KimmelmanGeorge Q Daley
Mar 2, 2016·Annual Review of Immunology·Susanne H BaumeisterArlene H Sharpe
May 18, 2016·Drug Discovery Today·Giulia AdrianiRoger Dale Kamm
May 18, 2016·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Kenji MurataToshihiko Torigoe
May 18, 2016·Journal of Ovarian Research·Gloria MitticaGiorgio Valabrega
May 28, 2016·Molecular Therapy Oncolytics·Daniel Abate-Daga, Marco L Davila
May 20, 2016·Annual Review of Pathology·Scott B Lovitch, Scott J Rodig
Jun 15, 2016·Journal of Immunology Research·Hilde AlmåsbakMohan C Vemuri
May 4, 2016·Expert Review of Hematology·Manjusha Namuduri, Renier J Brentjens
May 22, 2016·Current Oncology Reports·Aharon RonsonJ M Rowe
Sep 14, 2016·Expert Review of Precision Medicine and Drug Development·Elaine MaggiCristina Montagna
May 23, 2016·Current Hematologic Malignancy Reports·Manali I Patel
Jun 4, 2016·Molecular Therapy. Methods & Clinical Development·Sandeep Rp KumarRoland W Herzog
May 26, 2016·Expert Opinion on Emerging Drugs·Rupen DesaiJohn H Sampson
May 26, 2016·British Journal of Haematology·Paul Gaynon, Weili Sun
Apr 8, 2016·Blood·Megan D Hoban, Daniel E Bauer
May 28, 2016·Pediatric Blood & Cancer·Francesco CeppiOussama Abla
Jun 5, 2016·Comptes rendus biologies·Alain Fischer
Jun 9, 2016·Advanced Drug Delivery Reviews·Kelly A Schwarz, Joshua N Leonard
Jun 4, 2016·Scientific Reports·Mireya Paulina VelasquezStephen M Gottschalk
Jun 6, 2016·International Journal of Hematology·Marco L Davila, Michel Sadelain
Jun 9, 2016·The Journal of Clinical Investigation·Carlos A RamosGianpietro Dotti
Jun 11, 2016·Current Problems in Pediatric and Adolescent Health Care·P Pallavi MadhusoodhanTeena Bhatla
Jul 11, 2016·Clinical Lymphoma, Myeloma & Leukemia·Monzr M Al MalkiVinod Pullarkat
Jun 12, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Bernard MayburyKarthik Ramasamy
Jun 14, 2016·The New England Journal of Medicine·Hagop M KantarjianAnjali S Advani
May 26, 2016·Expert Opinion on Biological Therapy·Myrna R Nahas, David Avigan
May 21, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hiroki Torikai, Laurence J N Cooper
Jun 21, 2016·Human Vaccines & Immunotherapeutics·Szun Szun TayMaté Biro
Jun 19, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ramzi AbboudRizwan Romee
Jun 28, 2016·Pharmacology & Therapeutics·Daniel DelittoSteven J Hughes
Jun 28, 2016·CA: a Cancer Journal for Clinicians·Alexander Shimabukuro-VornhagenMichael S von Bergwelt-Baildon
Nov 8, 2015·The Lancet Oncology·Hideho OkadaDavid A Reardon
May 22, 2016·Blood·Emma C Morris, Hans J Stauss
May 22, 2016·Blood·Jennifer N Brudno, James N Kochenderfer
Jun 21, 2016·Expert Review of Hematology·Cameron J Turtle, David Maloney
Jul 7, 2016·Immunotherapy·Toshio TanakaTadamitsu Kishimoto
Jul 9, 2016·Blood·Cynthia E Dunbar
Jul 12, 2016·Cancers·Ida SilvestriAlessandro Sciarra
Jul 13, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Challice L BonifantStephen M Gottschalk
Jul 20, 2016·Human Genetics·Xiaoyi LiAndrea Ventura
Jul 23, 2016·Blood·Anna-Karin E Palm, Patrick C Wilson
Nov 21, 2015·Journal of Immunology Research·Michael A HuangKenneth G Lucas
Jul 20, 2016·Expert Opinion on Biological Therapy·Yi Lin, Hideho Okada
Aug 1, 2016·Current Hematologic Malignancy Reports·Marco Ruella, Carl H June
Aug 3, 2016·The Journal of Clinical Investigation·Partow KebriaeiLaurence J N Cooper
Jul 1, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mikko SiuralaAkseli Hemminki
Aug 6, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Federico LussanaAlessandro Rambaldi
Jul 30, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Naeem K PatilEdward R Sherwood
Aug 9, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Erik Oude BlenkeJohn van der Oost
Aug 9, 2016·Trends in Biotechnology·Mohamed Abou-El-EneinDavid W Grainger
May 14, 2016·Clinical Pharmacology and Therapeutics·Cameron J TurtleDavid Maloney
Jul 31, 2016·Experimental Hematology·Xiaoou Zhou, Malcolm K Brenner
Jul 20, 2016·Immunology and Cell Biology·Ling YiHongtao Zhang
Aug 21, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David T Teachey, Stephan A Grupp
Jul 13, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·M Kazim PanjwaniNicola J Mason
Aug 23, 2016·The Journal of Clinical Investigation·Yuki KagoyaNaoto Hirano
May 11, 2016·Journal of Cellular Physiology·Albert T GacerezCharles L Sentman
Jul 7, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ursula J E SeidelPeter Lang
Oct 16, 2016·Best Practice & Research. Clinical Haematology·Januario E Castro, Thomas J Kipps
Aug 25, 2016·Pediatric Research·Tina L ChengScott C Denne
Aug 30, 2016·The Journal of Clinical Investigation·Marco RuellaSaar Gill
Sep 11, 2016·Cancer Immunology, Immunotherapy : CII·Astrid HolzingerHinrich Abken
Sep 26, 2016·Blood Reviews·Geoffrey S KannanDean A Lee
Apr 29, 2016·BJU International·Jennifer M Mataraza, Philip Gotwals
Sep 15, 2016·The New England Journal of Medicine·Sébastien Mauryfor GRAALL
Sep 18, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Saad KenderianSaar Gill
Dec 8, 2015·Hematology·Lisa Humphrey, Tammy I Kang
Dec 8, 2015·Hematology·Rachel Kobos, William Terry
Dec 8, 2015·Hematology·Sarah A Buckley, Roland B Walter
Sep 20, 2016·Biochimica Et Biophysica Acta·Lang Yi, Jinming Li
Sep 24, 2016·Blood Cancer Journal·Nicola GökbugetHagop M Kantarjian
Oct 21, 2016·Computational and Structural Biotechnology Journal·Marco Ruella, Marcela V Maus
Oct 1, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Melinda Mata, Stephen M Gottschalk
Jul 22, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jenessa B SmithDaniel J Powell
Oct 11, 2016·Mechanisms of Ageing and Development·Clara Soria-VallesCarlos López-Otín
Oct 13, 2016·The New England Journal of Medicine·Masayuki Amagai
Oct 21, 2016·The Journal of Clinical Investigation·Paulina J PaszkiewiczDirk H Busch
Oct 26, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Annalisa RuggeriJean Hugues Dalle
Nov 12, 2016·Frontiers in Pharmacology·Tetsuro SasadaYuki Fujimoto
Nov 9, 2016·Trends in Molecular Medicine·Hazem E GhoneimBen Youngblood
Oct 21, 2016·Expert Opinion on Pharmacotherapy·Xavier Thomas, Caroline Le Jeune
Nov 30, 2016·British Journal of Haematology·Rayne H RouceHelen E Heslop
Dec 2, 2016·AIDS Patient Care and STDs·Thor A Wagner
Dec 14, 2016·PLoS Medicine·Mack Y Su, David E Fisher
Dec 16, 2016·British Journal of Haematology·Robert Z OrlowskiNoelle V Frey
Oct 31, 2015·Neuro-oncology·David A ReardonLinda Liau
Dec 22, 2016·Immunotherapy·Shunichiro KuramitsuAtsushi Natsume
Dec 28, 2016·Cell Research·Rong-Fu Wang, Helen Y Wang
Dec 28, 2016·Cell Research·Laura A Johnson, Carl H June
Dec 25, 2015·PloS One·Hannah KarlssonAngelica Loskog
Nov 20, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B Bonavida, S Chouaib
Jan 8, 2017·Annual Review of Pharmacology and Toxicology·Michael R Yeaman, John P Hennessey
Jan 28, 2017·Immunotherapy·Jonathan E CohenMichal Lotem
Jan 29, 2016·Journal of the National Cancer Institute·Hanren DaiWeidong Han
Jan 27, 2017·Science Translational Medicine·Waseem QasimP Veys
Dec 19, 2016·Expert Opinion on Drug Safety·S Harrison FarberJohn H Sampson
Jan 13, 2017·Pharmacotherapy·Brandon R ShankSandra B Horowitz
Feb 6, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Felipe BedoyaMarcela V Maus
Jan 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chan Yoon CheahMichael L Wang
Feb 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Don S DizonGregory Masters
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey S WeberMary L Disis
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jae H Park, Renier J Brentjens
Mar 2, 2017·The New England Journal of Medicine·Hagop M KantarjianMax S Topp
Nov 9, 2016·Expert Opinion on Emerging Drugs·Françoise Huguet, Suzanne Tavitian
Feb 17, 2017·Leukemia·Daniel SommermeyerStanley Riddell
Mar 28, 2017·Journal of Surgical Oncology·Carl J DeSelmPrasad S Adusumilli
Apr 6, 2017·Transfusion·Megan M Suhoski DavisPhilip J Norris
Apr 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin J Curran, Renier J Brentjens
Apr 7, 2017·Bulletin of Mathematical Biology·Anne TalkingtonRick Durrett
Feb 7, 2017·Expert Review of Clinical Pharmacology·Allison A AkaScott A Waldman
Mar 23, 2017·Pharmacology & Therapeutics·Jason J Lohmueller, Olivera J Finn
Apr 13, 2017·Critical Reviews in Biochemistry and Molecular Biology·Michael HudecekZoltán Ivics
Mar 23, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joshua C Cyktor, John W Mellors
Apr 22, 2017·Cancer Treatment Reviews·Leo RascheFaith E Davies
Dec 23, 2016·Immunology and Cell Biology·Carmen S M YongMichael H Kershaw
Apr 30, 2017·Expert Opinion on Biological Therapy·Frederick L Locke, Marco L Davila
Dec 22, 2016·Clinical and Experimental Immunology·S JollesJ Litzman
May 12, 2017·Expert Review of Clinical Immunology·Masashi NarazakiTadamitsu Kishimoto
Apr 20, 2017·Clinical and Experimental Immunology·Trishan VaikunthanathanGiovanna Lombardi
May 26, 2017·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Daiki KatoYutaka Kawakami
Mar 30, 2017·Current Hematologic Malignancy Reports·Ankit J Kansagra, Mark R Litzow
May 27, 2017·Expert Opinion on Therapeutic Targets·Man-Hsin Hung, Kuen-Feng Chen
Jun 7, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Ryan K DasGuptaAnthony J Perissinotti
Apr 15, 2017·The Cancer Journal·David A Braun, Catherine J Wu
Feb 17, 2017·Current Oncology Reports·Nicholas J Short, Elias Jabbour
Jan 24, 2017·The Cancer Journal·Efrat Merhavi-ShohamMichal J Besser
Jan 25, 2017·Journal for Immunotherapy of Cancer·Sarah Haebe, Oliver Weigert
Jun 14, 2017·Expert Opinion on Pharmacotherapy·Raoul SantiagoHenrique Bittencourt
Apr 4, 2017·HLA : Immune Response Genetics·H-J Kolb
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liu YangSheng Hu
Mar 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jeffrey S UppermanRobert F Tamburro
Mar 31, 2017·Journal of Hematology & Oncology·Shengnan YuKongming Wu
Feb 1, 2017·Molecular Cancer·Kouki NioShuichi Kaneko
Apr 19, 2017·Journal of Surgical Oncology·Nancy D Ebelt, Edwin R Manuel
Apr 14, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Deboki ChakravartiWilson W Wong
Jul 1, 2017·Blood Cancer Journal·T Terwilliger, M Abdul-Hay
Jun 27, 2017·Expert Review of Anticancer Therapy·Joanna PierroWilliam L Carroll
Jul 1, 2017·Expert Review of Hematology·Gautam Kishore ValechaTerenig Terjanian
Jun 7, 2017·Expert Opinion on Biological Therapy·Robyn A A Oldham, Jeffrey A Medin
Jul 15, 2017·Human Vaccines & Immunotherapeutics·Ryan Zander, Weiguo Cui
Jul 11, 2017·Expert Review of Anti-infective Therapy·Jon HuygheLinos Vandekerckhove
Oct 4, 2016·Therapeutic Advances in Hematology·Nikolaos Papadantonakis, Anjali S Advani
Feb 3, 2016·Therapeutic Advances in Hematology·Kazusa Ishii, Austin J Barrett
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stewart Sell
Jul 22, 2017·Expert Opinion on Biological Therapy·Susanna GalloFilippo Montemurro
Jul 27, 2017·Leukemia & Lymphoma·Ibrahim Aldoss, Anthony S Stein
Oct 1, 2016·Archives of Disease in Childhood. Education and Practice Edition·Anna Capsomidis, John Anderson
Nov 25, 2017·Clinical Pharmacology and Therapeutics·Colleen AnnesleyRebecca A Gardner
Jan 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shivani Srivastava, Stanley Riddell
Feb 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Fabian MüllerIra Pastan
Feb 13, 2018·Nature Reviews. Clinical Oncology·David T TeacheyStephan A Grupp
Jan 26, 2018·Cancer Chemotherapy and Pharmacology·Sabeeh-Ur-Rehman Butt, Laeeq Malik
Mar 14, 2018·Expert Review of Anticancer Therapy·Brooke L PrinzingGiedre Krenciute
Mar 15, 2018·Expert Opinion on Investigational Drugs·Roland B Walter
Aug 30, 2017·International Journal of Molecular Sciences·Beatriz Martín-AntonioAlvaro Urbano-Ispizua
Jan 9, 2018·Expert Opinion on Biological Therapy·Sofia GentaGiorgio Valabrega
Feb 3, 2018·Human Gene Therapy·Elizabeth L Siegler, Pin Wang
Mar 9, 2018·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Antonia L Pritchard
Feb 27, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jae H ParkSusan K Seo
Dec 16, 2017·Nucleic Acids Research·Remus S WongChristina D Smolke
Mar 4, 2018·Current HIV/AIDS Reports·Thor A Wagner
Jan 25, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G Manson, R Houot
Feb 15, 2018·Current Hematologic Malignancy Reports·Victor M Orellana-Noia, Michael G Douvas
Dec 1, 2017·Current Opinion in Pediatrics·Liora M SchultzCrystal L Mackall
Nov 28, 2017·Current Opinion in Pediatrics·Jessica B Foster, Shannon L Maude
Mar 27, 2018·The Journal of Gene Medicine·Samantha L GinnMohammad R Abedi
Apr 17, 2018·Human Molecular Genetics·Cui ZhangJinfu Wang
Jul 7, 2017·Gene Therapy·D A Monfort, P Koria
Apr 27, 2018·Biomarkers in Medicine·Weimin KongJoseph A Fraietta
Feb 7, 2018·Frontiers in Immunology·Aurélie DurgeauFathia Mami-Chouaib
Nov 22, 2017·Journal for Immunotherapy of Cancer·Adam Ajina, John Maher
Nov 17, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Marco Ruella, Saad Kenderian
Nov 23, 2017·Frontiers in Immunology·Gianfranco PittariBenedetto Bruno
Nov 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Louise SentmanCharles L Sentman
Sep 1, 2017·Expert Opinion on Biological Therapy·Sonia ValletKlaus Podar
Nov 25, 2017·Blood·Shannon L Maude
Nov 25, 2017·Blood·Samantha Jaglowski
Nov 2, 2017·Einstein·Giulliana Augusta Rangel Gonçalves, Raquel de Melo Alves Paiva
Jan 13, 2018·Microbiology and Molecular Biology Reviews : MMBR·Jean-François GélinasStephen C Hyde
Feb 23, 2018·JCI Insight·Mireia Uribe-HerranzAndrea Facciabene
Oct 31, 2017·Annals of Hematology·Dan YangYanli Xu
Oct 3, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lia GoreGregory Reaman
Sep 1, 2017·Nature Reviews. Clinical Oncology·Jennifer N Brudno, James N Kochenderfer
Oct 19, 2017·Current Hematologic Malignancy Reports·Nathan SinghMarco Ruella
Nov 22, 2017·Current Treatment Options in Oncology·Adalgisa Condoluci, Davide Rossi
Dec 5, 2017·Médecine sciences : M/S·Bertrand Jordan
Mar 9, 2018·Case Reports in Oncology·Frank F Piraino
Jun 24, 2017·World Journal of Clinical Oncology·Songchuan GuoJennifer Wu
May 8, 2018·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Daniel J PallinGary H Lyman
Nov 3, 2017·Proceedings of the National Academy of Sciences of the United States of America·Heiko SchusterPhilipp Wagner
Jun 2, 2016·Therapeutic Advances in Urology·Akhil MuthigiPiyush K Agarwal
May 31, 2016·Therapeutic Advances in Medical Oncology·Joshua M BaumlCharu Aggarwal
Dec 6, 2017·Therapeutic Advances in Hematology·Trent Peng WangStefan Klaus Barta
Sep 21, 2017·Blood·Lekha Mikkilineni, James N Kochenderfer
Jul 18, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cameron J TurtleDavid Maloney
Sep 20, 2017·Nature Reviews. Clinical Oncology·Sattva S NeelapuElizabeth J Shpall
Dec 7, 2017·Human Gene Therapy·Alexandra MartyniszynHinrich Abken
Apr 8, 2016·Nature Biotechnology·Thomas Blankenstein
Aug 24, 2016·Nature Reviews. Cancer·Andrew D FesnakBruce L Levine
Jan 24, 2018·Blood·Melody SmithMichel Sadelain
May 10, 2018·Journal of Drug Targeting·Duy Hieu TruongTuan Hiep Tran
Jun 7, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric J ChowElizabeth Fox
Aug 5, 2017·Immunotherapy·Wan-Ning WangWen-Long Zhang
Jan 18, 2018·Immunotherapy·Syed Ammer ShahMasoud H Manjili
Mar 27, 2018·Annual Review of Chemical and Biomolecular Engineering·Johan KarlssonJordan J Green
Oct 5, 2017·Future Oncology·Philip M Arlen
Jan 27, 2018·Immunotherapy·Beom K ChoiByoung S Kwon
Jun 16, 2018·Nature Reviews. Drug Discovery·Patrick A MayesAxel Hoos
Mar 9, 2018·Cancer Gene Therapy·Albert T Gacerez, Charles L Sentman
Dec 3, 2017·Current Medical Research and Opinion·Caroline L Furness, David I Marks
Oct 24, 2017·Leukemia & Lymphoma·Zachary J RobertsAntoni Ribas
Jul 5, 2018·The New England Journal of Medicine·Carl H June, Michel Sadelain
Jun 27, 2018·Expert Opinion on Investigational Drugs·Marcus P Watkins, Nancy L Bartlett
Jun 29, 2018·Expert Opinion on Therapeutic Patents·Matthew HarrisDavid Bailey
Jul 10, 2018·Nature Biotechnology·Li TangDarrell J Irvine
Mar 3, 2018·Science·Crystal L Mackall
Mar 22, 2018·Frontiers in Immunology·Sharon Wei Ling LeeSiew Cheng Wong
Aug 4, 2018·Clinical Medicine : Journal of the Royal College of Physicians of London·Charlotte GrahamReuben Benjamin
Aug 6, 2017·Cold Spring Harbor Perspectives in Biology·Toshio TanakaTadamitsu Kishimoto
Nov 7, 2017·Leukemia & Lymphoma·Arnab GhoshRenier J Brentjens
Nov 4, 2017·F1000Research·Jan Starý, Ondřej Hrušák
Aug 30, 2018·Human Gene Therapy·Michael Alexander Morgan, Axel Schambach
Aug 3, 2018·Current Oncology Reports·Mekdem Tesfaye, Barbara Savoldo
Jul 20, 2018·Current Opinion in Organ Transplantation·Trishan VaikunthanathanGiovanna Lombardi
Aug 17, 2018·Expert Review of Anticancer Therapy·Allison Barz LeahyDavid T Teachey
Sep 7, 2018·Immunotherapy·Thomas T DeLeonMitesh J Borad
Sep 14, 2018·Current Protocols in Cytometry·Sindhu Cherian, Maryalice Stetler-Stevenson
Sep 22, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Renato BassanSabina Chiaretti
Sep 23, 2018·Clinical and Translational Science·Luis G Rodriguez-CartagenaAlexandra J Greenberg-Worisek
Mar 11, 2018·Molecular Neurobiology·Vishal Jindal
Sep 5, 2018·Annals of Neurology·Jacqueline S GofshteynJennifer L McGuire
Oct 3, 2018·Critical Reviews in Clinical Laboratory Sciences·Milena MusicEleftherios P Diamandis
Aug 21, 2018·Current Opinion in Oncology·Juan MontoroManuel Guerreiro
Oct 15, 2018·Journal of Cellular Physiology·Hamid Reza MirzaeiJamshid Hadjati
Oct 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Sophie ViaudTravis S Young
Jan 19, 2018·Leukemia & Lymphoma·Emma Bergfelt LennmyrSwedish Adult Acute Lymphoblastic Leukemia Group, SVALL
Jul 3, 2015·The Journal of Rheumatology·Randy Q CronWalter W Chatham
May 10, 2016·F1000Research·Jose C Villasboas, Stephen M Ansell
Nov 3, 2018·CNS Drugs·Juliane GustCameron J Turtle
Oct 6, 2016·F1000Research·Preeti Sharma, David M Kranz
Jun 16, 2016·F1000Research·Daniele C Cary, B Matija Peterlin
Aug 8, 2018·Nature Reviews. Clinical Oncology·Kris M MahadeoPediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Dec 18, 2018·Journal of Cellular Biochemistry·Solmaz ShirjangMehdi Yousefi
Dec 13, 2018·Current Opinion in Obstetrics & Gynecology·Bruce SchaarOliver Dorigo
Jan 19, 2018·Bone Marrow Transplantation· Amro ElshouryGeorge L Chen
Nov 9, 2018·Clinical Pharmacology and Therapeutics·Trevor R BaybuttAdam E Snook
Aug 6, 2018·Annals of the Rheumatic Diseases·David T EwartClifford J Steer
Dec 7, 2018·British Journal of Cancer·Katharina KriegsmannMichael Hundemer
Nov 17, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Motohiro Kato, Atsushi Manabe
Feb 2, 2018·Biomarker Research·Zhenguang Wang, Weidong Han
Jan 23, 2019·Advanced Healthcare Materials·Eun Sook LeeJae Hyung Park
Jan 27, 2018·Cell Death & Disease·Tatiana V DenisenkoBoris Zhivotovsky