Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy

Arthritis Research & Therapy
Carol M ArtlettLisa G Rider

Abstract

Microchimeric cells have been studied for over a decade, with conflicting reports on their presence and role in autoimmune and other inflammatory diseases. To determine whether microchimeric cells were pathogenic or mediating tissue repair in inflammatory myopathies, we phenotyped and quantified microchimeric cells in juvenile idiopathic inflammatory myopathies (JIIM), muscular dystrophy (MD), and noninflammatory control muscle tissues. Fluorescence immunophenotyping for infiltrating cells with sequential fluorescence in situ hybridization was performed on muscle biopsies from ten patients with JIIM, nine with MD and ten controls. Microchimeric cells were significantly increased in MD muscle (0.079 ± 0.024 microchimeric cells/mm(2) tissue) compared to controls (0.019 ± 0.007 cells/mm(2) tissue, p = 0.01), but not elevated in JIIM muscle (0.043 ± 0.015 cells/mm(2)). Significantly more CD4+ and CD8+ microchimeric cells were in the muscle of patients with MD compared with controls (mean 0.053 ± 0.020/mm(2) versus 0 ± 0/mm(2) p = 0.003 and 0.043 ± 0.023/mm(2) versus 0 ± 0/mm(2) p = 0.025, respectively). No differences in microchimeric cells between JIIM, MD, and noninflammatory controls were found for CD3+, Class II+, CD25+, CD45RA...Continue Reading

References

Apr 29, 1998·The New England Journal of Medicine·C M ArtlettS A Jimenez
Feb 24, 2001·Lancet·A M ReedD W Kredich
Oct 11, 2001·Arthritis and Rheumatism·K L JohnsonD W Bianchi
Nov 16, 2001·Rheumatology·C M ArtlettUNKNOWN Childhood Myositis Heterogeneity Collaborative Study Group
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kirby L JohnsonDiana W Bianchi
Oct 11, 2003·Obstetrics and Gynecology·Donghyun ChaKirby L Johnson
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ann M ReedCarole Ober
Dec 21, 2004·Annals of the Rheumatic Diseases·K KhosrotehraniK L Johnson
Oct 15, 2005·Current Opinion in Rheumatology·James G Tidball, Michelle Wehling-Henricks
Jun 23, 2007·Annals of the Rheumatic Diseases·Idske C L Kremer HovingaIngeborg M Bajema
Jan 15, 2008·American Journal of Obstetrics and Gynecology·Anna Maria JonssonMagnus Westgren
Mar 15, 2008·Reproductive Biomedicine Online·Keelin O'DonoghueNicholas M Fisk
Oct 23, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Anne M StevensJ Lee Nelson
Apr 1, 2009·Arthritis and Rheumatism·Consuelo M López De PadillaAnn M Reed
Apr 21, 2010·Muscle & Nerve·Sahil Khanna, Ann M Reed
Jun 10, 2010·Pediatric Research·Anna Maria JonssonMagnus Westgren
Dec 24, 2010·Nature Reviews. Endocrinology·Laura FugazzolaPaolo Beck-Peccoz
Feb 18, 2011·Chimerism·Berendine VanzylKathleen M Gillespie
Sep 14, 2011·Chimerism·David L SuskindMarcus O Muench
Jan 25, 2012·Rheumatology·Yi YeUNKNOWN Juvenile Dermatomyositis Research Group
Nov 3, 2012·Seminars in Neurology·Kevin M Flanigan
Feb 8, 2013·International Journal of Cancer. Journal International Du Cancer·Eugen DhimoleaPeter Geck
Mar 8, 2013·Lancet·Eugenio Mercuri, Francesco Muntoni

❮ Previous
Next ❯

Citations

Aug 28, 2018·Current Opinion in Rheumatology·Iago Pinal-Fernandez, Andrew L Mammen
Aug 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·German TapiaKetil Størdal
Dec 8, 2020·Frontiers in Immunology·Jeffery A GoldsteinAlison D Gernand

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

Prism

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.