PMID: 15369726DOI: 10.1016/j.clinbiochem.2004.05.020Sep 17, 2004Paper
Chimeric LNA/DNA probes as a detection system for real-time PCR
Clinical Biochemistry
Jean-Marc CostaKhalil Arar
Abstract
Evaluation of the use of short probes as a detection system in real-time PCR. Comparison of results obtained with hybridization probes with and without locked nucleic acid (LNA) residues in the detection of fetal DNA in maternal serum. The use of chimeric LNA/DNA probes led to a slight but significantly higher level of sensitivity as well as a higher level of fluorescence signal. Chimeric LNA/DNA probes offer an interesting alternative detection method in real-time PCR.
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