Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery

Chemical Communications : Chem Comm
Nithya SubramanianSubramanian Krishnakumar

Abstract

A chimeric aptamer-DNAzyme conjugate was generated for the first time using a nucleolin aptamer (NCL-APT) and survivin Dz (Sur_Dz) and exhibited the targeted killing of cancer cells. This proof of concept of using an aptamer for the delivery of DNAzyme can be applied to other cancer types to target survivin in cancer cells in a specific manner.

References

Oct 1, 1995·Chemistry & Biology·R R Breaker, G F Joyce
Dec 9, 2000·Experimental Cell Research·A G HovanessianB Krust
Sep 22, 2005·Journal of Gastroenterology and Hepatology·Zhiyong LiangTonghua Liu
Apr 3, 2008·Cancer Research·Sridharan SoundararajanDaniel J Fernandes
May 21, 2009·Experimental and Molecular Pathology·Paula J BatesJohn O Trent
Nov 19, 2010·Expert Opinion on Therapeutic Patents·Jagat R KanwarRupinder K Kanwar
Oct 1, 2011·Critical Reviews in Biochemistry and Molecular Biology·Jagat R KanwarRupinder K Kanwar
Jan 10, 2012·Biosensors & Bioelectronics·Cheng YangXiurong Yang
Mar 15, 2012·Lancet·Helen DimarasBrenda L Gallie
Jun 13, 2012·Medicinal Research Reviews·Jagat R KanwarRupinder K Kanwar
Jun 19, 2012·Nucleic Acid Therapeutics·Jonathan W KotulaBruce A Sullenger
Mar 5, 2013·Cancer Treatment Reviews·Mohane Selvaraj CoumarChun Hei Antonio Cheung
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Min ZhangSu Luo
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Le YangYa-Dong Sun
Jun 28, 2013·Pediatric Blood & Cancer·Job SudhakarJyotirmay Biswas
Jan 5, 2014·The British Journal of Ophthalmology·Job SudhakarSubramanian Krishnakumar
Jan 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong-Jie DuYi-Ming Hu
Jan 29, 2014·Journal of Cancer Research and Clinical Oncology·Hirota FujikiMasami Suganuma
Aug 6, 2014·Molecular Therapy. Nucleic Acids·Hongguang SunYouli Zu
May 27, 2010·Pharmaceuticals·Partha Ray, Rebekah R White

❮ Previous
Next ❯

Citations

Jul 3, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hongguang Sun, Youli Zu
Sep 4, 2015·Nucleic Acid Therapeutics·Nithya SubramanianSubramanian Krishnakumar
Jun 21, 2016·Journal of Pediatric Hematology/oncology·Jaisy SamuelSubramanian Krishnakumar
Jul 30, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Somayeh VandghanooniYadollah Omidi
Oct 9, 2018·Current Medicinal Chemistry·Fen HeYanfei Liu
Jun 23, 2021·Chemical Reviews·Abhichart KrissanaprasitThomas H LaBean
Oct 31, 2019·ACS Nano·Martin PanigajKirill A Afonin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Biology & Therapy
Leisha A Emens
Methods in Molecular Biology
D C Altieri
Molecular Therapy : the Journal of the American Society of Gene Therapy
Vittorio de Franciscis
Zhonghua bing li xue za zhi Chinese journal of pathology
Ping XieJun-chuan Li
© 2021 Meta ULC. All rights reserved