Chimeric RNAs and their implications in cancer

Current Opinion in Genetics & Development
Zi LiHui Li

Abstract

Chimeric RNAs have been believed to be solely produced by gene fusions resulting from chromosomal rearrangement, thus unique features of cancer. Detected chimeric RNAs have also been viewed as surrogates for the presence of gene fusions. However, more and more research has demonstrated that chimeric RNAs in general are not a hallmark of cancer, but rather widely present in non-cancerous cells and tissues. At the same time, they may be produced by other mechanisms other than chromosomal rearrangement. The field of non-canonical chimeric RNAs is still in its infancy, with many challenges ahead, including the lack of a unified terminology. However, we believe that these non-canonical chimeric RNAs will have significant impacts in cancer detection and treatment.

Citations

Jun 5, 2019·Genome Biology·Antonin Morillon, Daniel Gautheret
Oct 28, 2019·International Journal of Molecular Sciences·Vincenza BarresiDaniele Filippo Condorelli
Aug 6, 2020·BMC Medical Genomics·Stefanie Friedrich, Erik L L Sonnhammer
Feb 10, 2021·Non-coding RNA·Kenzui Taniue, Nobuyoshi Akimitsu

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