Abstract
A 65-year-old Japanese male was diagnosed as multiple myeloma with Bence Jones kappa type, clinical stage IIIA. His disease status reached partial remission after chemotherapy. Thereafter, he received tandem transplantation, consisting of high-dose chemotherapy with autologous stem cell transplantation (ASCT), followed by unrelated cord blood transplantation (U-CBT). U-CBT with a reduced-intensity conditioning regimen (RI-CBT) was performed in August 2003. HLA mismatch between the patient and the CBT donor was present at two serological loci (B and DR). A total nucleated CBT cell dose of 2.45 x 10(7)/kg body weight was infused on day 0. Graft-vs.-host disease (GVHD) prophylaxis consisted of cyclosporine A and short-term methotrexate. Neutrophil engraftment (>0.5 x 10(9)/l) was obtained on day 46. He developed positive cytomegalovirus antigenemia, grade II acute GVHD involving skin and liver, varicella-zoster virus infection, septic shock, hemorrhagic cystitis caused by adenovirus and acute hepatitis B virus infection after U-CBT. We retrospectively analyzed T-cell receptor (TCR) repertoire diversity and found that TCR repertoire diversity decreased continuously after U-CBT. Therefore, low-TCR repertoire diversity in this patien...Continue Reading
References
Jun 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G GahrtonP Jacobs
Mar 29, 2000·Bone Marrow Transplantation·E OrsiniJ Ritz
Jul 10, 2001·British Journal of Haematology·S MarianiM Massaia
Feb 7, 2002·Blood·Kimmo TalvensaariAntoine Toubert
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ashraf BadrosGuido Tricot
Jun 8, 2002·Acta Haematologica·Y TsutsumiM Imamura
Jul 20, 2002·Blood·Nicolaus KrögerAxel Rolf Zander
Oct 24, 2002·Blood·Nicolaus KrögerAxel Rolf Zander
Jan 11, 2003·Blood·Satkiran S GrewalJohn E Wagner
Jan 21, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Theresa HahnPhilip L McCarthy
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcella SarzottiRebecca H Buckley
Apr 3, 2003·British Journal of Haematology·José A Pérez-SimónJesús F San Miguel
May 9, 2003·The New England Journal of Medicine·J Anthony ChildUNKNOWN Medical Research Council Adult Leukaemia Working Party
May 10, 2003·Blood·Juliet N BarkerJohn E Wagner
Jul 12, 2003·Blood·David G MaloneyRainer Storb
Dec 26, 2003·The New England Journal of Medicine·Michel AttalUNKNOWN InterGroupe Francophone du Myélome
May 11, 2004·Bone Marrow Transplantation·M MohtyD Blaise
May 27, 2004·Leukemia & Lymphoma·Yutaka TsutsumiMasahiro Imamura
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shigesaburo MiyakoshiShuichi Taniguchi
Dec 24, 2004·International Journal of Hematology·Toshiki YamadaShigetaka Asano
Jan 19, 2005·European Journal of Haematology·Toshihiko AndoYukio Tanizawa
Feb 26, 2005·Blood·Charles CrawleyUNKNOWN Chromic Leukaemia Working Party of the EBMT
Mar 25, 2005·Scandinavian Journal of Immunology·P HentschkeM Remberger
Dec 24, 2005·British Journal of Haematology·Hiroto NarimatsuShuichi Taniguchi