The presence of cells or tissues from two individuals, chimeras, or the presence of cells and tissues that include the gonads, tetragametic chimerism can be detected by the analysis of cytogenetics and analysis of polymorphic genetic markers, using patterns of pedigree inheritance. These methodologies include determination of sex chromosomes, major histocompatibility complex (MHC) polymorphisms and panels of short tandem repeats (STRs) that include mitochondrial DNA markers. Studies routinely involve cases of temporal chimerism in blood transfusion, or following allotransplantation to measure the outcome of the organ, lymphopoietic tissues or bone marrow grafts. Demonstration of persistent chimerism is usually discovered in cases of inter-sexuality due to fusion of fraternal twins or in cases of fusion of embryos with demonstrable allogeneic monoclonality of blood which, excluded maternity or paternity when blood alone is used as the source of DNA. In single pregnancies it is possible to produce two kinds of microchimerism: feto-maternal and materno-fetal, but in cases of fraternal twin pregnancies it is possible to identify three different kinds which are related to cases of vanishing twins that can be identified during pregna...Continue Reading
Effect of neuraminidase on the expression of the 3-fucosyl-N-acetyllactosamine antigen in human tissues
In vitro fertilization and cleavage of a single egg from a binovular follicle containing two individual eggs surrounded by a single zona pellucida
Gene control of hematopoiesis. I. Erythrocyte mosaicism and permanent immunological tolerance in allophenic mice
Fertilization and cleavage of oocytes from a binovular human ovarian follicle: a possible cause of dizygotic twinning and chimerism
A human dispermic chimaera first suspected from analyses of the blood group gene-specified glycosyltransferases
Confined placental chimerism: prenatal and postnatal cytogenetic and molecular analysis, and pregnancy outcome
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
Cell-mediated cytotoxicity: a predictor of chronic rejection in pediatric HLA haploidentical renal transplants
Transfer of nucleated maternal cells into fetal circulation during the second trimester of pregnancy
Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands
Cutting edge: persistent fetal microchimerism in T lymphocytes is associated with HLA-DQA1*0501: implications in autoimmunity
Identification of arterio-venous anastomoses in vivo in monochorionic twin pregnancies: preliminary report
Lack of evidence for an increased microchimerism in the circulation of patients with Sjögren's syndrome
In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb
A dispermic chimera was identified in a healthy man with mixed field agglutination reaction in ABO blood grouping and mosaic 46, XY/46, XX karyotype
Analysis of maternal microchimerism in rhesus monkeys (Macaca mulatta) using real-time quantitative PCR amplification of MHC polymorphisms
Immune reactivity to type VII collagen: implications for gene therapy of recessive dystrophic epidermolysis bullosa
Zygotes segregate entire parental genomes in distinct blastomere lineages causing cleavage-stage chimerism and mixoploidy
Allogenic & Autologous Therapies
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Blood And Marrow Transplantation
The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.
Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.