Abstract
We have studied the peripheral T cell repertoire of two patients with severe combined immunodeficiency who were successfully treated with human histocompatibility leukocyte antigen (HLA)-mismatched fetal liver stem cell transplantation. The patients presented a split chimerism. T cells were of donor origin, whereas the B cells/monocytes were of the host phenotype. Interestingly, the natural killer (NK) cells in one patient were donor derived and in the other patient of host origin. The NK cells were functional but did not have antihost or donor reactivity. Despite the HLA mismatch between donor and host cells, complete tolerance was achieved in vivo, and a specific unresponsiveness of peripheral blood mononuclear cells from both patients toward the host cells was demonstrated in vitro. Nevertheless, we could isolate T cell receptor (TCR)alpha beta, CD4+ or CD8+, T cell clones specifically reacting with HLA class I and II molecules of the host. The CD4+ host-reactive T cell clones from both patients produced interleukins 2 and 5, interferon-gamma, granulocyte/macrophage colony-stimulating factor but are specifically defective in interleukin 4 production. The frequencies of CD8+ host-reactive T cells were high, and were in the sa...Continue Reading
References
Apr 16, 1992·Nature·F A HardingJ P Allison
Apr 1, 1992·The Journal of Experimental Medicine·B A VandekerckhoveM G Roncarolo
Apr 1, 1992·The Journal of Experimental Medicine·J H PhillipsL L Lanier
Jun 1, 1992·Immunological Reviews·J S AbramsJ E Silver
Oct 1, 1992·Immunology Today·L L LanierJ H Phillips
Jan 1, 1992·Tissue Antigens·L GebuhrerH Betuel
Oct 1, 1990·Transplantation·W R DrobyskiR L Truitt
Oct 6, 1990·Lancet·A FischerR Levinsky
Jan 1, 1991·The Journal of Experimental Medicine·M J DallmanP J Morris
Jun 15, 1990·Science·R H Schwartz
May 1, 1990·The Journal of Experimental Medicine·T MiyawakiN Taniguchi
Aug 1, 1990·Immunological Reviews·A BensussanL Boumsell
May 1, 1990·The Journal of Experimental Medicine·C M ParkerM B Brenner
Sep 1, 1990·Human Immunology·C A KeeverR J O'Reilly
Aug 1, 1990·Immunological Reviews·H SpitsM G Roncarolo
Aug 1, 1990·Immunological Reviews·A F TilkinJ P Levy
Dec 1, 1988·The Journal of Experimental Medicine·M G RoncaroloH Spits
Nov 1, 1989·The Journal of Experimental Medicine·G CasoratiN Migone
Aug 1, 1988·The Journal of Experimental Medicine·C BottinoA Moretta
Feb 19, 1987·Nature·J BorstR L Bolhuis
Jun 1, 1985·The Journal of Experimental Medicine·K A AultB R Smith
May 1, 1988·The Journal of Experimental Medicine·M G RoncaroloH Spits
Mar 1, 1986·The Journal of Clinical Investigation·M G RoncaroloJ Banchereau
Feb 1, 1986·European Journal of Immunology·J P De VillartayA Fischer
Apr 1, 1987·The Journal of Experimental Medicine·W J MurphyM Bennett
Mar 1, 1981·Human Immunology·J L Touraine, H Bétuel
Feb 1, 1995·Current Opinion in Immunology·P Scott, G Trinchieri
Citations
Aug 31, 2000·Biochemical and Biophysical Research Communications·H NagahoraY Okamura
Oct 6, 2007·Immunologic Research·Jean-Louis TouraineLucette Gebuhrer
Dec 1, 1993·Immunology Letters·J L TouraineH Spits
Apr 1, 1994·Current Opinion in Immunology·H Spits
Sep 12, 2003·Transplant Immunology·Nicole Suciu-FocaRaffaello Cortesini
Feb 1, 1994·The Journal of Experimental Medicine·R BacchettaM G Roncarolo
Jul 1, 1996·The Journal of Experimental Medicine·H GrouxM G Roncarolo
Oct 1, 1995·Scandinavian Journal of Immunology·J MilosevitsG G Petrányi
Aug 31, 2011·Journal of Transplantation·Jean-Louis Touraine, Kamel Sanhadji
Jun 10, 1998·Springer Seminars in Immunopathology·A FischerM Cavazzana-Calvo
Jun 1, 1985·Cellular Immunology·R L Bolhuis, R J van de Griend
Apr 6, 2005·Transplantation Proceedings·J-L TouraineL Gebuhrer
Aug 28, 2002·Immunity·Loïc DupréMaria-Grazia Roncarolo
Jan 23, 2015·Frontiers in Pharmacology·Andrea I LoewendorfAlan Flake
Nov 28, 2014·Frontiers in Pharmacology·William H Peranteau
Oct 31, 2006·Epilepsy & Behavior : E&B·Ivan OsorioDavid Morrison
Sep 10, 2016·PloS One·Ann-Kathrin UhdeAndreas Beineke
Aug 20, 2010·Cell Transplantation·Jeng-Chang ChenRen-Huei Fu
Dec 29, 1995·Annals of the New York Academy of Sciences·H GrouxM G Roncarolo
Aug 19, 2007·Journal of Internal Medicine·M Sykes
Oct 3, 2002·Nature Reviews. Immunology·Hergen Spits
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Henry W MurrayFrederick P Heinzel
May 23, 2006·Infection and Immunity·Maria del Pilar JimenezJoshua Fierer
Mar 24, 2005·Infection and Immunity·Laurence U Buxbaum, Phillip Scott
Oct 16, 2002·Infection and Immunity·Henry W MurrayRobert L Coffman
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M K LevingsM G Roncarolo