Chinese herbal medicine for Mild Cognitive Impairment and Age Associated Memory Impairment: a review of randomised controlled trials

Biogerontology
Brian MayCharlie Changli Xue

Abstract

This review assesses the effectiveness and safety of Chinese herbal medicines (CHM) for Mild Cognitive Impairment (MCI) and Age Associated Memory Impairment (AAMI). Electronic searches of English and Chinese databases and hand searches of Chinese journal holdings were conducted. Randomised controlled trials comparing orally administered CHM with placebo, no intervention or other therapy were considered. Ginkgo biloba was excluded. Ten trials met inclusion criteria. Eight different CHM were investigated. Methodological quality was assessed using the Jadad scale and five studies scored three or above. Two studies compared CHM with placebo and eight with another intervention. This review found an overall benefit on some outcome measures for the eight CHMs involved in the 10 RCTs but methodological and data reporting issues were evident. Meta-analysis of three studies found the effects of the CHMs were at least equivalent to piracetam on Mini-Mental State Examination (MMSE) scores. No severe adverse events were reported.

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Citations

Oct 16, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Brian H MayCharlie C L Xue
Mar 29, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Lin DongBrian H May
May 19, 2020·International Journal of Geriatric Psychiatry·Zijun XuSamuel Yeungshan Wong
Feb 12, 2017·Nature Reviews. Neurology·Dennis W SimonPatrick M Kochanek
Mar 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yujin ChoiJun-Hwan Lee
Apr 15, 2021·Phytotherapy Research : PTR·Nafiseh Ghassab-AbdollahiMojgan Mirghafourvand

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