Abstract
Intrauterine growth restriction complicates 5-10% of pregnancies. This study aims to test the hypothesis that Chinese herbal formula, JLFC01, affects pregnancy and fetal development by modulating the pro-inflammatory decidual micro-environment. Human decidua from gestational age-matched elective terminations or incomplete/missed abortion was immunostained using anti-CD68 + anti-CD86 or anti-CD163 antibodies. qRT-PCR and Luminex assay measured the effects of JLFC01 on IL-1β- or TNF-α-induced cytokine expression in first trimester decidual cells and on an established spontaneous abortion/intrauterine growth restriction (SA/IUGR)-prone mouse placentae. The effect of JLFC01 on human endometrial endothelial cell angiogenesis was evaluated by average area, length and numbers of branching points of tube formation. Food intake, litter size, fetal weight, placental weight and resorption rate were recorded in SA/IUGR-prone mouse treated with JLFC01. qRT-PCR, Western blot and immunohistochemistry assessed the expression of mouse placental IGF-I and IGF-IR. In spontaneous abortion, numbers of decidual macrophages expressing CD86 and CD163 are increased and decreased, respectively. JLFC01 reduces IL-1β- or TNF-α-induced GM-CSF, M-CSF, C-C m...Continue Reading
References
Jul 1, 1995·The Journal of Experimental Medicine·A D LusterP Leder
Apr 1, 1997·Nature Medicine·N KlauberR J D'Amato
Mar 10, 1998·Molecular Reproduction and Development·S N Abu-AmeroG E Moore
Jan 12, 1999·British Journal of Obstetrics and Gynaecology·R P HolmesP W Soothill
May 18, 1999·Placenta·R HolmesP Soothill
Feb 24, 2000·Biology of Reproduction·F SchatzC J Lockwood
Sep 5, 2002·Nature Reviews. Immunology·Ashley Moffett-King
Jan 30, 2003·Journal of Leukocyte Biology·David M Mosser
Mar 7, 2003·Biology of Reproduction·Peter KaufmannBerthold Huppertz
Sep 18, 2003·Placenta·Abigail L Fowden
Jan 17, 2004·American Journal of Reproductive Immunology : AJRI·Sandra BloisRicardo A Margni
Nov 27, 2004·Endocrinology·Luigi LaviolaFrancesco Giorgino
Apr 14, 2006·Hormone Research·C Gicquel, Y Le Bouc
Jun 30, 2006·Journal of Reproductive Immunology·S J HuangC J Lockwood
Feb 23, 2007·Psychology and Psychotherapy·Fátima Serrano, Maria Luisa Lima
Dec 12, 2007·The Journal of Pathology·S J HuangC J Lockwood
Mar 11, 2008·Trends in Endocrinology and Metabolism : TEM·Malathi Srinivasan, Mulchand S Patel
May 1, 2008·PloS One·Charlotte GustafssonJan Ernerudh
Aug 22, 2008·Immunological Investigations·Stephen J Renaud, Charles H Graham
Aug 18, 2009·Thrombosis Research·Min Li, S Joseph Huang
Feb 19, 2010·American Journal of Reproductive Immunology : AJRI·Takeshi Nagamatsu, Danny J Schust
Sep 11, 2010·The American Journal of Pathology·S Joseph HuangCharles J Lockwood
Jun 29, 2011·Seminars in Reproductive Medicine·Mark S Longtine, D Michael Nelson
Nov 24, 2011·PloS One·Enrique ZudaireSonja Vermeren
Jan 4, 2012·Placenta·Z M WuS J Huang
Sep 8, 2012·Biology of Reproduction·B Anne CroyScott A Gerber
Citations
Apr 3, 2019·International Journal of Molecular Sciences·Chiara AgostinisRoberta Bulla
May 1, 2019·Frontiers in Immunology·Yongli YaoLiping Jin
May 21, 2020·Molecular Human Reproduction·Yongli YaoLiping Jin
Nov 14, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Daisuke ShigemiHideo Yasunaga