Chinese medicine formula DSQRL versus glucocorticoids for the treatment of experimental pulmonary fibrosis

Journal of Ethnopharmacology
Hong-Qi ZhangMin Li

Abstract

Pulmonary fibrosis (PF) is a devastating interstitial lung disease that may develop idiopathically or as a complication of many other diseases. The outcome of the current main treatment by glucocorticoids is by no means satisfactory. This study has tested a new Chinese medicine Decoction for Strengthening Qi and Replenishing Lung (DSQRL) for the treatment of experimental PF in comparison with prednisolone. Eighty-five rats with PF induced by CCl(4) were randomly divided into 4 groups to undertake treatment either by (a) high dose of prednisolone; (b) Chinese medicine formula DSQRL; (c) combined treatment of the above two; or (d) sham feeding of water in equal volume. At the end of 60 days treatment, the DSQRL treatment achieved a significantly better outcome than prednisolone in terms of general behavior, histological examination, hydroxyproline content of the lung and inflammatory cell counts in bronchoalveolar lavage fluid. Thus, the newly proposed Chinese medicinal formula DSQRL appears to be a better and promising option for PF than glucocorticoids for the treatment of PF.

References

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Jun 14, 2006·Thorax·Robin M RuddUNKNOWN Fibrosing Alveolitis Subcommittee of the Research Committee of the British Thoracic Society
Sep 22, 2006·Journal of Ethnopharmacology·Hong-Qi ZhangMin Li

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Citations

Nov 17, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jiao YangMartin Kolb
Dec 9, 2017·Frontiers in Pharmacology·Xiaoyi LiRuixin Zhu
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhiqing ShenKeji Chen

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