Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry IX: Clinical Features and Survival of Childhood-Onset Systemic Lupus Erythematosus in China

Chinese Medical Journal
Chan-Yuan WuCSTAR co-authors

Abstract

Approximately 15-20% cases of systemic lupus erythematosus (SLE) are diagnosed in children. There have been a few studies reporting the epidemiological data of pediatric-onset SLE (cSLE) in China, neither comparing the differences between cSLE and adult-onset SLE (aSLE). The aim of this study was to describe the impact of age of onset on clinical features and survival in cSLE patients in China based on the Chinese SLE Treatment and Research group (CSTAR) database. We made a prospective study of 225 cSLE patients (aged Results: The mean age of cSLE patients was 12.16 ± 2.92 years, with 187 (83.1%) females. Fever (P < 0.001) as well as mucocutaneous (P < 0.001) and renal (P = 0.006) disorders were found to be significantly more frequent in cSLE patients as initial symptoms, while muscle and joint lesions were significantly less common compared to aSLE subjects (P < 0.001). The cSLE patients were found to present more frequently with malar rash (P = 0.001; odds ratio [OR], 0.624; 95% confidence interval [CI], 0.470-0.829) but less frequently with arthritis (P < 0.001; OR, 2.013; 95% CI, 1.512-2.679) and serositis (P = 0.030; OR, 1.629; 95% CI, 1.053-2.520). There was no significant difference in SLE disease activity index scores b...Continue Reading

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Citations

Sep 21, 2017·Clinical Rheumatology·Liying PengXiaofeng Zeng
Nov 30, 2018·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Abdel Masieh MetrySuad Hannawi
May 23, 2018·Chinese Medical Journal·Dong-Ni ChenXue-Qing Yu
Jul 30, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Louise OniKjell Tullus
Jun 1, 2021·International Journal of Rheumatic Diseases·Nasra K Al-AdhoubiHumaid A Al Wahshi

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