Chiral discrimination using piezoelectric and optical gas sensors

Nature
K BodenhöferW Göpel

Abstract

Odour perception in humans can sometimes discriminate different enantiomers of a chiral compound, such as limonene. Chiral discrimination represents one of the greatest challenges in attempts to devise selective and sensitive gas sensors. The importance of such discrimination for pharmacology is dear, as the physiological effect of enantiomers of drugs and other biologically active molecules may differ significantly. Here we describe two different sensor systems that are capable of recognizing different enantiomers and of qualitatively monitoring the enantiomeric composition of amino-acid derivatives and lactates in the gas phase. One sensor detects changes in mass, owing to binding of the compound being analysed (the 'analyte'), by thickness shear-mode resonance; the other detects changes in the thickness of a surface layer by reflectometric interference spectroscopys. Both devices use the two enantiomers of a chiral polymeric receptor, and offer rapid on-line detection of chiral species with high selectivity.

Citations

Feb 9, 2005·Analytical and Bioanalytical Chemistry·Guenter Gauglitz
Oct 22, 2013·Analytica Chimica Acta·Marek Trojanowicz, Marzena Kaniewska
Feb 24, 2001·Journal of Chromatography. a·N M MaierW Lindner
Jul 4, 1998·Trends in Biotechnology·T A DickinsonD R Walt
Sep 11, 2013·Physical Chemistry Chemical Physics : PCCP·Yongli ZhangJianping Gao
Jan 1, 2010·Sensors·Katsuhiko ArigaJonathan P Hill
Aug 3, 2012·The Journal of Chemical Physics·Andreas Jacob, Klaus Hornberger
May 2, 2014·Nature Communications·Takuya OhzonoJun-ichi Fukuda
Jan 7, 2017·Journal of the American Chemical Society·Jinqiao DongYong Cui
Feb 8, 2006·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Marco Bieri, Thomas Bürgi
Nov 5, 2003·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jong Hwa JungToshimi Shimizu
Jun 5, 1997·Nature·A P Turner
Aug 2, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Kuei-Lin ChanChi-Young Lee
Apr 20, 1999·Nature Biotechnology·O HofstetterB S Green
Apr 22, 2008·Nature Materials·Luisa TorsiFrancesco Naso
Apr 2, 2019·Analytical and Bioanalytical Chemistry·Farabi TemelMustafa Tabakci
Feb 3, 2007·Physical Chemistry Chemical Physics : PCCP·Marco BieriThomas Bürgi
Nov 15, 2019·Chemistry : a European Journal·Chularat Wattanakit, Alexander Kuhn
Jun 4, 2020·The Journal of Chemical Physics·Yu-Yuan ChenYong Li
Mar 14, 2014·Chemistry : a European Journal·Hiroki IidaEiji Yashima
Jul 10, 2019·Physical Review Letters·Alexander A MilnerIlya Sh Averbukh
Aug 2, 2020·Analytical and Bioanalytical Chemistry·Alexandru Oprea, Udo Weimar
Jul 30, 2016·Physical Review Letters·Andrey Yachmenev, Sergei N Yurchenko
Feb 7, 2003·Physical Review Letters·Petr KrálDoron Cohen
Dec 26, 2001·Chemical Reviews·K J AlbertD R Walt
Aug 16, 2003·Analytical Chemistry·P DuttaM J Sepaniak
Jul 12, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Changhua XuHardy Sze On Chan
Oct 17, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Huanyao CunHong-Jun Gao
Jan 31, 2002·Journal of the American Chemical Society·Takuya NakanishiKohei Uosaki
Feb 9, 2018·The Journal of Physical Chemistry Letters·Ilia TutunnikovIlya Sh Averbukh
Mar 6, 2019·ACS Applied Materials & Interfaces·Manuela StefanelliDonato Monti
Jan 18, 2008·Chemical Reviews·Andreas Hierlemann, Ricardo Gutierrez-Osuna
Jul 30, 2004·Journal of the American Chemical Society·Bahar BehzadiKarl-Heinz Ernst

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