Chiral enrichment of serine via formation, dissociation, and soft-landing of octameric cluster ions

Journal of the American Society for Mass Spectrometry
Sergio C NanitaDavid E Clemmer

Abstract

Chiral enrichment of serine is achieved in experiments that involve formation of serine octamers starting from non-racemic serine solutions. Serine octamers were generated by means of electrospray and sonic spray ionization of aqueous solutions of d(3)-L-serine (108 Da) and D-serine (105 Da) having different molar ratios of enantiomers. A cyclic process involving the formation of chirally-enriched octameric cluster ions and their dissociation, viz. Ser(1) --> Ser(8) --> Ser(1), allows serine monomers to be regenerated with increased enantiomeric excess as shown in two types of experiments: (1) Chiral enrichment in serine was observed in MS/MS/MS experiments in a quadrupole ion trap in which the entire distribution of serine octamers formed from non-racemic solutions was isolated, collisionally activated, and fragmented. Monomeric serine was regenerated with increased enantiomeric excess upon dissociation of octamers when compared with the enantiomeric composition of the original solution. (2) Chiral enrichment was observed in the products of soft-landing of mass-selected protonated serine octamers. These ions were generated by means of electrospray or sonic spray ionization, mass selected, and collected on a gold surface using ...Continue Reading

References

Jun 20, 1978·Journal of Molecular Evolution·W A Bonner, R M Lemmon
Jan 1, 1984·Methods in Enzymology·J L Bada
Dec 5, 1998·Science·M M Green, J V Selinger
Nov 11, 1999·Angewandte Chemie·M M GreenJ V Selinger
Jul 6, 2000·Nature·G L Rikken, E Raupach
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·C M DobsonV Vaida
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·R M HazenG A Goodfriend
Dec 18, 2001·Chirality·R HodyssJ L Beauchamp
Mar 28, 2003·Analytical Chemistry·Zoltan TakatsKaroly Vekey
Apr 23, 2003·Analytical Chemistry·Mark Hardman, Alexander A Makarov
Aug 6, 2003·Angewandte Chemie·Zoltan TakatsR Graham Cooks
Aug 16, 2003·Science·Zheng OuyangR Graham Cooks
Nov 18, 2003·Analytical Chemistry·Zoltan TakatsR Graham Cooks
Feb 7, 2004·Chemical Communications : Chem Comm·Zoltán Takáts, R Graham Cooks
Apr 1, 2004·Journal of the American Chemical Society·Ryan R JulianDavid E Clemmer

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Citations

Mar 10, 2007·Journal of the American Society for Mass Spectrometry·Sergio C NanitaR Graham Cooks
Mar 9, 2011·Chemical Reviews·Isabelle Weissbuch, Meir Lahav
Aug 24, 2012·Chemical Reviews·Jobin CyriacR G Cooks
Nov 30, 2006·Annual Review of Physical Chemistry·Thomas Wyttenbach, Michael T Bowers
Mar 5, 2011·Annual Review of Analytical Chemistry·Grant E JohnsonJulia Laskin
Apr 17, 2015·Mass Spectrometry Reviews·Grant E JohnsonJulia Laskin
May 21, 2015·Nature Chemistry·Yongju Yun, Andrew J Gellman
Jun 7, 2012·The Journal of Physical Chemistry. a·Alison E HollidayDavid E Clemmer
May 2, 2014·The Journal of Physical Chemistry. B·Subha PratiharWilliam L Hase
Feb 28, 2007·Chemical Communications : Chem Comm·Richard H PerryR Graham Cooks
Mar 15, 2006·European Journal of Mass Spectrometry·Ulf Mazurek
Nov 12, 2017·Journal of the American Society for Mass Spectrometry·Alexander D JacobsDavid E Clemmer
Apr 7, 2005·Physical Chemistry Chemical Physics : PCCP·Bogdan GologanR Graham Cooks
Jan 13, 2006·Angewandte Chemie·Sergio C Nanita, R Graham Cooks
Feb 14, 2008·Physical Chemistry Chemical Physics : PCCP·Julia LaskinOmar Hadjar
Nov 26, 2010·Physical Chemistry Chemical Physics : PCCP·Anthony B Costa, R Graham Cooks
Nov 24, 2017·Nature Chemistry·Jongcheol SeoGert von Helden
Aug 18, 2012·The Analyst·Guido VerbeckBarbara Walton
Nov 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yingying ShiXianglei Kong
Aug 8, 2008·Analytical Chemistry·Wen-Ping PengR Graham Cooks
Apr 13, 2006·Chemical Reviews·D J Donaldson, Veronica Vaida
Apr 12, 2018·Journal of the American Chemical Society·Valeriu ScutelnicJongcheol Seo
Dec 21, 2006·Journal of the American Chemical Society·Pengxiang YangR Graham Cooks
May 17, 2007·Analytical Chemistry·Michael VolnýFrantisek Turecek
Jan 27, 2006·The Journal of Physical Chemistry. a·Jormarie AlvarezJulia Laskin

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