Chiral Isocamphoric Acid: Founding a Large Family of Homochiral Porous Materials

Angewandte Chemie
Xiang ZhaoXianhui Bu

Abstract

Homochiral metal-organic frameworks (MOFs) are an important class of chiral solids with potential applications in chiral recognition; however, relatively few are available. Of great importance is the availability of low-cost, racemization-resistant, and versatile enantiopure building blocks. Among chiral building blocks, d-camphoric acid is highly prolific, yet, its trans-isomer, l-isocamphoric acid, has remained unknown in the entire field of solid-state materials. Its rich yet totally untapped synthetic and structural chemistry has now been investigated through the synthesis of a large family of homochiral metal isocamphorates. The first observation of diastereoisomerism in isostructural MOFs is presented. Isocamphorate has a powerful ability to create framework topologies unexpected from common inorganic building blocks, and isocamphoric acid should allow access to hundreds of new homochiral materials.

References

Apr 20, 2005·Accounts of Chemical Research·D BradshawM J Rosseinsky
Mar 31, 2007·Journal of the American Chemical Society·Zhuojia LinRussell E Morris
Oct 31, 2007·Journal of the American Chemical Society·Jian ZhangXianhui Bu
Apr 23, 2009·Chemical Society Reviews·Liqing MaWenbin Lin
Apr 24, 2010·Nature Chemistry·Russell E Morris, Xianhui Bu
Oct 1, 2011·Chemical Communications : Chem Comm·Mohan PadmanabanStefan Kaskel
Aug 15, 2012·Journal of the American Chemical Society·Pengyan WuChunying Duan
May 2, 2013·Chemical Communications : Chem Comm·Mei ZhangLi-Ming Yuan
Jun 19, 2013·Chemical Communications : Chem Comm·Hao WangXian-He Bu
Aug 16, 2013·Journal of the American Chemical Society·Cheng WangWenbin Lin
Feb 14, 2014·Chemical Communications : Chem Comm·Junkuo GaoQichun Zhang
Dec 6, 2014·Accounts of Chemical Research·Debasis BanerjeePraveen K Thallapally
May 13, 2015·Chemical Communications : Chem Comm·Jun ZhaoQichun Zhang
Nov 26, 2015·Journal of the American Chemical Society·Shi-Yuan ZhangMichael J Zaworotko
Mar 30, 2016·Chemical Society Reviews·Zhi-Gang GuXianhui Bu
Jun 14, 2016·Nature Communications·Debasis BanerjeePraveen K Thallapally
Oct 21, 2016·Advanced Materials·Bin LiBanglin Chen
Aug 20, 2016·Science·Seungkyu LeeOmar M Yaghi
Feb 22, 2017·Chemistry : a European Journal·Zhanfeng JuBanglin Chen
Dec 14, 2017·Journal of the American Chemical Society·Dong LuoDan Li

❮ Previous
Next ❯

Citations

May 12, 2021·Chemical Society Reviews·Juan LiuJian Zhang
Oct 24, 2018·Journal of the American Chemical Society·Xiang ZhaoXianhui Bu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.