Chiral mesoporous silica synthesized by a facile strategy for loading and releasing poorly water-soluble drug.

Drug Development and Industrial Pharmacy
Zibin GaoYanping Sun

Abstract

Most of the mesoporous chiral mesoporous silica (CMS) was synthesized by the chiral surfactant-directing method. In this study, a facile method was designed to synthesize CMS. In this method, achiral amphiphile was used as templating agents, and dilute ammonia solution was applied to induce the chirality of the CMS. Meanwhile, its morphology can be controlled by changing the concentration of the aqueous ammonia solution. The obtained CMS was characterized by dynamic light scattering (DLS), X-ray diffraction (XRD), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The results showed that all of the CMS possessed highly ordered mesostructures, and as the concentration of ammonia decreases, the chirality of the CMS becomes more obvious. Water-insoluble drug curcumin (Cur) was used as a model drug. The characteristics of CMS before and after drug loading were further detected by Fourier transform infrared spectrometer (FT-IR), N2 adsorption-desorption and differential scanning calorimetry (DSC). The result showed that Cur was successfully loaded inside the pores of the CMS and remained an amorphous state due to steric inhibition. Additionally, CMS could significantly increase the release rate of Cur un...Continue Reading

References

May 21, 2004·Nature·Shunai CheTakashi Tatsumi
Feb 19, 2005·Science·Yehuda Snir, Randall D Kamien
Sep 2, 2005·Chemical Communications : Chem Comm·Yonggang YangKenji Hanabusa
Feb 25, 2006·Angewandte Chemie·Bo WangYi Tang
Aug 10, 2006·Journal of the American Chemical Society·Sui YangDongyuan Zhao
Jan 16, 2007·Journal of Pharmaceutical Sciences·Shadi MadiehLarry Augsburger
Aug 2, 2008·The Journal of Physical Chemistry. B·Huibin Qiu, Shunai Che
Dec 17, 2008·Journal of Pharmaceutical Sciences·Michiel Van SpeybroeckPatrick Augustijns
Sep 20, 2012·International Journal of Pharmaceutics·Wujun XuVesa-Pekka Lehto
Jun 8, 2013·Journal of the American Chemical Society·Wenjing LiuZhiyong Tang
Feb 20, 2016·Drug Delivery and Translational Research·Sandeep Kalepu, Vijaykumar Nekkanti
Jan 1, 2019·Colloids and Surfaces. B, Biointerfaces·Na FanJing Li

❮ Previous
Next ❯

Citations

Sep 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mingshu CuiLu Xu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Mingshu CuiLu Xu
Medical Economics
Ken Terry
Psychopharmacology
F Borsini
Home Healthcare Nurse
Jeanie Stoker
© 2022 Meta ULC. All rights reserved