Chiral N,N Ligands Enabling Palladium-Catalyzed Enantioselective Intramolecular Heck-Matsuda Carbonylation Reactions by Sequential Migratory and CO Insertions

Angewandte Chemie
Rafaela C CarmonaCarlos Roque Duarte Correia

Abstract

Unprecedented enantioselective intramolecular Heck carbonylation reactions of arenediazonium salts were enabled by a chiral N,N ligand. This reaction constitutes the first enantioselective Heck carbonylation that proceeds through migratory insertion followed by CO insertion. The enantioenriched functionalized dihydrobenzofurans were obtained in good to high yields and enantiomeric ratios of up to 98:2 under mild and operationally simple reaction conditions.

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Citations

Oct 6, 2018·Chemistry : a European Journal·Shivashankar KattelaCarlos Roque D Correia
Nov 13, 2019·Chemical Communications : Chem Comm·Baihang JuWangqing Kong
Aug 4, 2020·Chemistry : a European Journal·Holly E BonfieldMarc Reid
May 28, 2021·Chemical Science·Zhiyang LinChuan Wang
Jun 12, 2021·Organic & Biomolecular Chemistry·Alexander N ReznikovYuri N Klimochkin
Jun 27, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Caio C Oliveira, Carlos Roque Duarte Correia
Aug 13, 2021·Journal of the American Chemical Society·Jin-Bao QiaoXing-Zhong Shu
Apr 20, 2019·Journal of the American Chemical Society·Zhi-Xiong TianXing-Zhong Shu
Dec 19, 2018·Journal of the American Chemical Society·Yernaidu ReddiRaghavan B Sunoj
Nov 11, 2020·Journal of the American Chemical Society·Yue LiMengchun Ye

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