Chiral polymer modified nanoparticles selectively induce autophagy of cancer cells for tumor ablation

Journal of Nanobiotechnology
Long YuanJun Deng

Abstract

Autophagy regulation through exogenous materials has aroused intensive attention to develop treatment protocols according to diverse human diseases. However, to the best of our knowledge, few examples have been reported to selectively control autophagy process and ultimately achieve efficient therapeutic potential. In this study, monolayers of poly (acryloyl-L, D and racemic valine) (L-PAV-AuNPs, D-PAV-AuNPs and L/D-PAV-AuNPs) chiral molecules were anchored on the surfaces of gold nanoparticles (PAV-AuNPs), and the subsequent chirality-selective effects on autophagy activation were thoroughly studied. The cytotoxicity induced by PAV-AuNPs towards MDA-MB-231 cells (Breast cancer cells) was achieved mainly through autophagy and showed chirality-dependent, with D-PAV-AuNPs exhibiting high autophagy-inducing activity in vitro and in vivo. In contrast, the PAV-AuNPs exhibited autophagy inactivation for normal cells, e.g., 3T3 fibroblasts and HBL-100 cells. The chirality-selective autophagy activation effect in MDA-MB-231 cells was likely attributed to the chirality-variant ROS generation, cellular uptake and their continuous autophagy stimulus. Furthermore, the intratumoral injection of D-PAV-AuNPs could largely suppress the tumor g...Continue Reading

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Citations

Feb 12, 2020·Journal of Biochemical and Molecular Toxicology·Yue ChenYong Xu
Mar 17, 2020·Chemical Society Reviews·Xueli ZhaoXiaoyuan Chen
Jul 30, 2019·Small Methods·Weijun WeiWeibo Cai
Nov 30, 2018·Cellular and Molecular Life Sciences : CMLS·Marco Cordani, Álvaro Somoza
Aug 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yue Wang, Yunsheng Xia
Nov 7, 2019·Advanced Materials·Jihyeon YeomAna Jaklenec
Jan 13, 2021·International Journal of Molecular Sciences·Amani Zoabi, Katherine Margulis
Jul 6, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Mohammad Reza SepandMohammad Raoufi
Jul 24, 2021·Journal of Nanobiotechnology·Zaihui PengXiaowei Qi
Oct 5, 2019·ACS Applied Materials & Interfaces·Xiaoqiu DouChuanliang Feng

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Methods Mentioned

BETA
immunoprecipitation assay
transmission electron microscopy
dynamic light scattering
circular dichroism
flow cytometry
surface plasmon resonance
transfection

Software Mentioned

Origin

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