Chiral Polypeptide Thermogels Induce Controlled Inflammatory Response as Potential Immunoadjuvants

ACS Applied Materials & Interfaces
Yue WangXuesi Chen

Abstract

The in vivo implanted biomaterials are known to induce inflammatory response and recruit immune cells, which could be used as robust adjuvants for immunotherapy. However, the degree of inflammatory response induced by the implanted biomaterials is hard to control. In this work, we reported the application of three kinds of thermogels from the polypeptide methoxy poly(ethylene glycol)-polyalanine (mPEG-PAla) with various chiralities to regulate the levels of inflammatory responses in vivo. The mPEG-PLAla (EG45LA28) and mPEG-PDAal (EG45DA27) thermogels exhibited comparable storage modulus ( G') and loss modulus ( G″), both of which were about two times higher than the values of the racemic mPEG-PAla (EG45RA) thermogel. The component d-alanine in the polypeptide thermogels led to controlled tissue inflammation after subcutaneous injection, and the content of d-alanine could adjust the level of inflammation. The expression of tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in subcutaneous tissue around the injected thermogel EG45DA27 were 3.62, 1.52, and 4.55 times the levels of those after EG45RA thermogel injection and 4.52, 7.38, and 7.96 times the levels of those after EG45LA28 injection, respect...Continue Reading

References

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Citations

Sep 12, 2019·Advanced Science·Xiangru FengXuesi Chen
Aug 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiangru FengJianxun Ding
Jun 4, 2020·Journal of Biomedical Materials Research. Part a·Tingting LiangLvhua Guo
Jun 26, 2020·Frontiers in Bioengineering and Biotechnology·Xi ZhangRui Li
Apr 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meishan ChenJianxun Ding
Oct 13, 2020·Frontiers in Bioengineering and Biotechnology·Yifu SunDuoyi Zhao
Nov 13, 2020·Journal of Biomaterials Science. Polymer Edition·María Luz TorresJuan Manuel Fernández
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Jie LiChangfeng Fu
Feb 2, 2021·Colloids and Surfaces. B, Biointerfaces·Yin XiaoXiaoai He
Jul 6, 2019·International Journal of Biological Macromolecules·Clara García-Astrain, Luc Avérous
Apr 16, 2021·Acta Biomaterialia·Jiayue ShiJiandong Ding
Jun 18, 2021·Light, Science & Applications·Da-Quan YangYun-Feng Xiao
Mar 8, 2019·Biomacromolecules·Yanbo ZhangXuesi Chen
Oct 4, 2021·Advanced Materials·Shengjie JiangYan Wei
Jan 12, 2022·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·S Rashia BegumCatalin I Pruncu
Jan 29, 2022·ACS Biomaterials Science & Engineering·Dong LiXuesi Chen

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