Chiral Primary Amine/Palladium Dual Catalysis for Asymmetric Allylic Alkylation of β-Ketocarbonyl Compounds with Allylic Alcohols

Angewandte Chemie
Han ZhouSanzhong Luo

Abstract

An efficient dual catalytic system composed of a chiral primary amine and a palladium complex was developed to promote the direct asymmetric allylic alkylation (AAA) of β-ketocarbonyl compounds. In particular, the synergistic dual catalytic system enabled the AAA reaction of challenging acyclic aliphatic ketones, such as β-ketocarbonyl compounds and 1,3-diketones.

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Citations

Apr 15, 2016·Journal of the American Chemical Society·Ren-Rong LiuYi-Xia Jia
Sep 14, 2016·Organic Letters·Yang Xiong, Guozhu Zhang
Feb 28, 2017·Journal of the American Chemical Society·Han ZhouSanzhong Luo
Jan 20, 2016·Chemical Communications : Chem Comm·Alberto BallesterosJose M González
Jul 8, 2017·Journal of the American Chemical Society·Xiaohong HuoWanbin Zhang
Apr 30, 2017·Chemistry : a European Journal·Igor D Jurberg
Jul 8, 2016·Chemical Communications : Chem Comm·Toyoharu KobayashiHisanaka Ito
Nov 10, 2017·Organic & Biomolecular Chemistry·Jingke FuWanbin Zhang
Nov 30, 2016·Angewandte Chemie·Lars A LethKarl Anker Jørgensen
Feb 6, 2019·Organic & Biomolecular Chemistry·Syeda Tazeen ZehraXinqiang Fang
Nov 28, 2017·Chemistry : a European Journal·Sunisa AkkarasamiyoJoseph S M Samec
Dec 20, 2017·Chemical Communications : Chem Comm·Xiaohong HuoWanbin Zhang
May 6, 2017·The Journal of Organic Chemistry·Bo Yang, Zhong-Xia Wang
Oct 20, 2017·The Journal of Organic Chemistry·Masanori Yoshida
Jan 18, 2020·Journal of the American Chemical Society·Yaning WangSanzhong Luo

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