Chiral purity of nucleotides as a necessary condition of complementarity

FEBS Letters
V I GoldanskiiV V Kuz'min

Abstract

This work discusses the question about the role of chiral purity (homochirality) of nucleotides in the formation of complementary replicas. A qualitative answer to this question can be obtained from molecular models constructed to simulate the chiral defect in the polynucleotidic chain. It shows the necessity of homochirality of nucleotides for the complementarity preservation. The necessity of the strong mirror-symmetry breaking in the abiogenic formation of the self-replicating oligonucleotide structures is discussed in the context of prebiological evolution.

References

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Citations

Nov 17, 2009·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Mark M Green, Vipul Jain
Nov 17, 2009·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Roni A IllosMeir Lahav
Jan 1, 1991·Bio Systems·V V Avetisov, V I Goldanskii
Jul 1, 1991·Physics Today·V A AvetisovV V Kuz'min
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·V Avetisov, V Goldanskii
Aug 8, 2009·Physical Review Letters·David Hochberg
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·David Hochberg
Mar 7, 2012·Chemical Communications : Chem Comm·Celia Blanco, David Hochberg
Jan 8, 2004·Experimental Biology and Medicine·Andrea T BorchersM Eric Gershwin
May 5, 2018·Journal of Molecular Evolution·Hemachander Subramanian, Robert A Gatenby
Aug 10, 2000·Journal of Theoretical Biology·N V Hud, F A Anet

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