Chiral Recognition and Separation by Chirality-Enriched Metal-Organic Frameworks

Angewandte Chemie
Saikat DasShilun Qiu

Abstract

Endowed with chiral channels and pores, chiral metal-organic frameworks (MOFs) are highly useful; however, their synthesis remains a challenge given that most chiral building blocks are expensive. Although MOFs with induced chirality have been reported to avoid this shortcoming, no study providing evidence for the ee value of such MOFs has yet been reported. We herein describe the first study on the efficiency of chiral induction in MOFs using inexpensive achiral building blocks and fully recoverable chiral dopants to control the handedness of racemic MOFs. This method yielded chirality-enriched MOFs with accessible pores. The ability of the materials to form host-guest complexes was probed with enantiomers of varying size and coordination and in solvents with varying polarity. Furthermore, mixed-matrix membranes (MMMs) composed of chirality-enriched MOF particles dispersed in a polymer matrix demonstrated a new route for chiral separation.

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Citations

Apr 5, 2019·Chemistry : a European Journal·Teppei YamadaNobuo Kimizuka
Apr 22, 2021·Chemical Communications : Chem Comm·Ming-Yue BiJian Zhang
Apr 30, 2021·Journal of the American Chemical Society·Anemar Bruno KanjLars Heinke
May 12, 2021·Chemical Society Reviews·Juan LiuJian Zhang
May 25, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Ruoyu CuiEnhong Sheng
Aug 4, 2021·ACS Applied Materials & Interfaces·Zhen-Zhang WengLan-Sun Zheng
Jun 12, 2019·Accounts of Chemical Research·Jesús M Fernández-GarcíaNazario Martín
Feb 25, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Minggao QinChuanliang Feng
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Aug 27, 2021·Journal of Chromatography. a·Yanlong ChenYuling Hu
Sep 16, 2021·Angewandte Chemie·Dipankar GhoshKrishna K Damodaran

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