Chiral recognition in adrenergic receptor binding mimics prepared by molecular imprinting

Journal of Molecular Recognition : JMR
O RamströmK Mosbach

Abstract

Molecularly imprinted polymers were prepared against the adrenomimetic agents ephedrine and pseudoephedrine. These compounds each incorporate two chiral centres. The polymers were evaluated with respect to enantiodiscrimination of various adrenergic ligands. The selectivity of the polymeric binding sites for the imprinted molecules was very high, and it was found that binding of both the enantiomeric and diastereomeric isomers of the imprint species were effectively obstructed, it was found that these polymers could selectively recognize the enantiomers of the endogenous adrenergic ligand epinephrine as well as several beta-adrenergic blockers. These observations suggest that these polymers effectively mimic the recognition patterns exhibited by natural adrenergic receptors.

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Citations

Apr 20, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Xiaojie XuLirong Chen
May 2, 2002·Biochimica Et Biophysica Acta·Pierre Lemay
Apr 1, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·R SuedeeG P Martin
Sep 21, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·L I Andersson
Jun 24, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·T Takeuchi, J Haginaka
Feb 27, 2003·Biosensors & Bioelectronics·M C Blanco-LópezP Tuñón-Blanco
Feb 1, 2006·Organic & Biomolecular Chemistry·Toshifumi TakeuchiHideyuki Shinmori
Aug 23, 2006·Journal of Molecular Recognition : JMR·Huiqi ZhangKlaus Mosbach
Mar 31, 2009·International Journal of Molecular Sciences·Roongnapa SuedeeBhutorn Canyuk
May 13, 2020·Physical Chemistry Chemical Physics : PCCP·Jordan DezalayGilles Grégoire
Oct 14, 2004·Analytical and Bioanalytical Chemistry·Vivek Babu Kandimalla, Hunagxian Ju
Jan 6, 2006·Journal of Molecular Recognition : JMR·Cameron AlexanderMichael J Whitcombe
Feb 24, 2001·Journal of Chromatography. a·B Sellergren
May 23, 2001·Journal of Agricultural and Food Chemistry·O RamströmO Brüggemann
Apr 8, 2006·The Journal of Organic Chemistry·Christophe Gomy, Andreea R Schmitzer

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