Chiral separation of omeprazole and several related benzimidazoles using supercritical fluid chromatography

Journal of Separation Science
M J del NozalJuan J Jiménez

Abstract

A study of the enantiomeric separation of omeprazole and several related benzimidazoles, using supercritical fluid chromatography (SFC), on the amylose based column Chiralpak AD is presented in this work. The effect of the organic modifier as well as temperature on the retention and enantioresolution was investigated. Alcohol-type modifiers provided the best results, allowing the enantiomeric separation of all the compounds studied with resolutions that were in most cases higher than 2, and analysis times lower than 10 minutes. An investigation of the temperature effect revealed that the isoelution temperature was below the working temperature range in only two cases, and hence it was better to work at the highest temperature permitted.

References

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Feb 5, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Q B CassJ Pedrazolli
Jan 25, 2003·Journal of Biochemical and Biophysical Methods·M J del NozalJ J Jiménez
Aug 20, 2003·Journal of Chromatography. a·Margareta E AnderssonGunnar Hagman
Oct 3, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ricardo Mathias Orlando, Pierina Sueli Bonato
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Citations

Feb 18, 2005·Analytical and Bioanalytical Chemistry·Karen W Phinney
Apr 8, 2014·Analytica Chimica Acta·Květa KalíkováEva Tesařová
Mar 1, 2012·Journal of Pharmaceutical and Biomedical Analysis·Katrijn De KlerckYvan Vander Heyden
Dec 1, 2015·Journal of Chromatography. a·Martin EnmarkTorgny Fornstedt
Aug 10, 2006·Journal of Separation Science·Laura ToribioJuan J Jiménez
Apr 11, 2008·Journal of Separation Science·Debby Mangelings, Yvan Vander Heyden
May 16, 2006·Digestive Diseases·Carmelo ScarpignatoFrancesco Di Mario
Jul 17, 2013·Journal of Separation Science·Lakshmi Narayana ChennuruPramod Kumar Dubey
Oct 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fei XiongLi Li
May 19, 2021·The Journal of Organic Chemistry·Gregory B CravenAlan Armstrong

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