Chiral separation of quinolones by liquid chromatography and capillary electrophoresis

Journal of Separation Science
Imran AliLeonid Asnin

Abstract

The quinolones are derivatives of oxoquinolines and mostly known for their antibacterial and antiviral activities. Many quinolones are chiral compounds having asymmetric centers and important due to their enantioselective biological activities. In order to study the biological activities of quinolone enantiomers, to control the manufacturing of homochiral drugs and to prepare necessary quantities of pure enantiomers for preclinical or clinical trials, respective chiral separation methods are urgently needed. In this context, the present review discusses chromatographic and electrophoretic methods for the enantioseparation of chiral quinolones and provides some useful information on their physical and pharmaceutical properties. The drawbacks of currently used techniques are revealed and ways to overcome them are outlined. Moreover, recommendations for an optimal choice of a separation protocol are given.

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Citations

Apr 7, 2018·Chirality·Rasha M HassanHassan Y Aboul-Enein
Mar 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana TeixeiraCarla Fernandes
Mar 12, 2020·Polymers·Imran AliJung-Chih Chen
Jun 15, 2020·The Journal of Chemical Physics·Fu-Jun LinBao-Quan Ai

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