Chiral separations in microemulsion electrokinetic chromatography. Use of micelle polymers and microemulsion polymers

Journal of Chromatography. a
Rashid IqbalShahab A Shamsi

Abstract

In this study, microemulsions of the chiral surfactant polysodium N-undecenoyl-D-valinate (poly-D-SUV) was utilized for enantiomeric separation by investigating two approaches using polymeric chiral surfactant in microemulsion electrokinetic chromatography (MEEKC). In the first approach, poly-D-SUV was used as an emulsifier surfactant along with 1-butanol and n-heptane. Enantioseparation of anionic or partially anionic binaphthyl derivatives, anionic barbiturates, and cationic paveroline derivatives were achieved by varying the mass fraction of 1-butanol, n-heptane and poly-D-SUV. For anionic or partially anionic analytes, relatively lower mass fractions of n-heptane, and poly-D-SUV were found to give optimum chiral separations as compared to that for cationic solutes. In the second approach, the chiral microemulsion polymer was prepared by polymerizing mixtures of 3.50% (w/w) of sodium N-undecenoyl-D-valinate (D-SUV) and 0.82% (w/w) of n-heptane (core phase) at varying concentration of 1-butanol. After polymerization, the n-heptane and 1-butanol were removed to yield solvent free microemulsion polymers (MPs) which were then utilized for the separation of anionic binaphthyl derivatives and anionic barbiturates. When MPs of D-SU...Continue Reading

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Citations

May 12, 2006·Electrophoresis·Ann Van Eeckhaut, Yvette Michotte
Dec 1, 2006·Electrophoresis·Gerald Gübitz, Martin G Schmid
Dec 1, 2006·Electrophoresis·Eamon McEvoyJoe Power
Mar 19, 2008·Journal of Separation Science·Christopher P Palmer
Nov 30, 2005·Electrophoresis·Carmen W Huie
Jan 21, 2014·Angewandte Chemie·Heike Lorenz, Andreas Seidel-Morgenstern

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