Chiral separations

Annual Review of Analytical Chemistry
A M Stalcup

Abstract

The main goal of this review is to provide a brief overview of chiral separations to researchers who are versed in the area of analytical separations but unfamiliar with chiral separations. To researchers who are not familiar with this area, there is currently a bewildering array of commercially available chiral columns, chiral derivatizing reagents, and chiral selectors for approaches that span the range of analytical separation platforms (e.g., high-performance liquid chromatography, gas chromatography, supercritical-fluid chromatography, and capillary electrophoresis). This review begins with a brief discussion of chirality before examining the general strategies and commonalities among all of the chiral separation techniques. Rather than exhaustively listing all the chiral selectors and applications, this review highlights significant issues and differences between chiral and achiral separations, providing salient examples from specific classes of chiral selectors where appropriate.

References

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Citations

Mar 30, 2016·Journal of Analytical Methods in Chemistry·Lixing NieShuangcheng Ma
Jan 22, 2013·Chirality·Elfi KrakaDieter Cremer
Apr 9, 2016·Nucleosides, Nucleotides & Nucleic Acids·Yan TangXiaoli Xiong
Sep 16, 2016·Chemical Research in Toxicology·Karan UppalDean P Jones
Oct 16, 2016·Scientific Reports·Sunghan RoYong Woon Kim
Oct 27, 2016·The Journal of Chemical Physics·Folarin LatinwoPablo G Debenedetti
Aug 25, 2018·Nature Reviews. Drug Discovery·Jonas BoströmGyörgy M Keserü
Apr 2, 2020·Annual Review of Chemical and Biomolecular Engineering·Saikat DasWei Wang
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Sep 17, 2020·Macromolecular Rapid Communications·Siqi ZhuoYibing Ji
May 13, 2017·Organic & Biomolecular Chemistry·P Renzi
Mar 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ankur GogoiGuan-Yu Zhuo
Jun 27, 2020·Angewandte Chemie·Shi-Yuan ZhangMichael J Zaworotko
Jan 15, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanan Huang, Alfonso E Garcia-Bennett
Mar 27, 2021·Journal of Chromatography. a·Albatul Y AlmushaytiMichael J Scotter
Mar 20, 2013·Chemical Reviews·Naomi L Kuehnbaum, Philip Britz-McKibbin
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Jun 22, 2013·Analytical Chemistry·Lajos Szente, Julianna Szemán
Mar 30, 2011·Analytical Chemistry·Stefan NaglDetlev Belder
Oct 8, 2011·Chemical Reviews·Jian-Rong LiHong-Cai Zhou
Jun 22, 2013·Journal of the American Chemical Society·Vincent Demers-CarpentierPeter H McBreen
Sep 3, 2021·The Journal of Chemical Physics·Nikolai D PetsevPablo G Debenedetti
Jul 9, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·R Bhushan, H Brückner

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Methods Mentioned

BETA
electrophoresis
Fluorescence
infrared spectroscopy
circular dichroism

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