Chirality in metal-based anticancer agents

Dalton Transactions : an International Journal of Inorganic Chemistry
Yi WangPingyu Zhang

Abstract

Chiral natural biological molecules, such as nucleic acids and proteins, guide the research of chiral compounds. Chiral metal-based drugs are currently an interesting and rapidly growing field in anticancer research. This perspective focuses on chiral metal compounds with application in cancer chemotherapy. The different chiral metal-based anticancer agents and the extent to which the chiral resolution affects their biological properties are discussed. This perspective will aid the design of new potent and efficient chiral metal-based anticancer drugs that exploit their unique properties combined with their potential selectivity toward targeted chiral biomolecules.

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Citations

Mar 15, 2018·Chemical Communications : Chem Comm·Yi WangPingyu Zhang
Oct 17, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Pingyu Zhang, Huaiyi Huang
Mar 20, 2020·Advanced Materials·Katsuhiko ArigaTakashi Uemura
Apr 8, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Makoto TsuruiYasuchika Hasegawa
May 28, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Tatyana E KokinaMark B Bushuev
Jun 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ružena ČižmárikováMário Markuliak
Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adedamola S ArojojoyeSamuel G Awuah
Apr 23, 2021·Organic & Biomolecular Chemistry·Cynthia L SchreiberBradley D Smith
Jul 12, 2019·Chemical Reviews·Kais DhbaibiJeanne Crassous
Dec 12, 2018·Journal of the American Chemical Society·Lucien N LameijerSylvestre Bonnet

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Methods Mentioned

BETA
circular dichroism

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