Chitin and its derivatives: Structural properties and biomedical applications.

International Journal of Biological Macromolecules
Syed Ishraque AhmadMd Imtaiyaz Hassan

Abstract

Chitin, a polysaccharide that occurs abundantly in nature after cellulose, has attracted the interest of the scientific community due to its plenty of availability and low cost. Mostly, it is derived from the exoskeleton of insects and marine crustaceans. Often, it is insoluble in common solvents that limit its applications but its deacetylated product, named chitosan is found to be soluble in protonated aqueous medium and used widely in various biomedical fields. Indeed, the existence of the primary amino group on the backbone of chitosan provides it an important feature to modify it chemically into other derivatives easily. In the present review, we present the structural properties of chitin, and its derivatives and highlighted their biomedical implications including, tissue engineering, drug delivery, diagnosis, molecular imaging, antimicrobial activity, and wound healing. We further discussed the limitations and prospects of this versatile natural polysaccharide.

Citations

Dec 16, 2020·Marine Drugs·Vida ŠimatFatih Özogul
May 18, 2021·International Journal of Biological Macromolecules·Iratxe ZarandonaPedro Guerrero
Jun 8, 2021·Advances in Colloid and Interface Science·Małgorzata JurakKlaudia Szafran
Sep 24, 2021·Critical Reviews in Food Science and Nutrition·Esmaeil SheibaniHermann Ehrlich

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