Chitin membrane for wound dressing application--preparation, characterisation and toxicological evaluation.

International Wound Journal
Rita SinghAdesh Kumar Mathur

Abstract

Chitin, a unique biopolymer based on the N-acetyl-glucosamine monomer is envisioned to promote rapid dermal regeneration and accelerate wound healing. It has many useful and advantageous biological properties for its application as a wound dressing. Chitin membranes were prepared using lithium chloride/dimethylacetamide solvent system and evaluated for use as a wound dressing. Swelling behaviour, moisture vapour transmission rate, microbial impermeability and antimicrobial efficacy of the dressings was evaluated. The chitin dressing provided an effective barrier to microbial penetration and exerted a broad bacteriostatic action against Gram-positive and Gram-negative organisms. Gamma irradiation at 25 kGy was found suitable for sterilisation of the dressings. The thermal decomposition of unirradiated and irradiated chitin membranes was investigated. No significant change in the thermal behaviour because of irradiation at 25 kGy was observed. In vitro biodegradation of unirradiated and irradiated chitin membranes showed the susceptibility of the chitin dressing to lysozyme. Irritant effect of the chitin membrane dressings on skin was tested. Subcutaneous and scarification test in guinea pigs showed no signs of inflammation. This...Continue Reading

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Citations

Aug 14, 2012·Journal of Materials Science. Materials in Medicine·Rita Singh, Durgeshwer Singh
Sep 11, 2012·International Wound Journal·Rita Singh, Durgeshwer Singh
Oct 16, 2015·Jundishapur Journal of Microbiology·Mahere Rezazade BazazMorteza Behnam Rassouli
Jun 15, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marius RădulescuMariana Carmen Chifiriuc
Aug 12, 2017·International Wound Journal·Rita SinghAntaryami Singh
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aurelia PoerioFranck Cleymand
Jan 13, 2017·Annals of Plastic Surgery·Hai-Fei LiuWilliam C Lineaweaver
Oct 24, 2017·International Journal of Cosmetic Science·E G Brunt, J G Burgess
Jul 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·J L ShamshinaR D Rogers
May 29, 2018·Carbohydrate Polymers·Periaswamy Sivagnanam SaravanaByung-Soo Chun

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