Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice

Marine Drugs
Junping ZhengHongtao Liu

Abstract

Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced metabolic syndrome by rebuilding the structure of the gut microbiota community. Male C57BL/6J mice fed with HFD were treated with NACOS (1 mg/mL) in drinking water for five months. The results indicate that NACOS improved glucose metabolic disorder in HFD-fed mice and suppressed mRNA expression of the protein regulators related to lipogenesis, gluconeogenesis, adipocyte differentiation, and inflammation in adipose tissues. Additionally, NACOS inhibited the destruction of the gut barrier in HFD-treated mice. Furthermore, 16S ribosome RNA sequencing of fecal samples demonstrates that NACOS promoted the growth of beneficial intestinal bacteria remarkably and decreased the abundance of inflammogenic taxa. In summary, NACOS partly rebuilt the microbial community and improved the metabolic syndrome of HFD-fed mice. These data confirm the preventive effects of NACOS on nutrient excess-related metabolic diseases.

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Citations

Jan 18, 2020·Annual Review of Food Science and Technology·Qixing NieMingyong Xie
Apr 23, 2019·Medicine·Juan JiaNing Xu
Dec 18, 2019·Journal of Gastroenterology·Haiming HuHongtao Liu
Feb 2, 2019·Experimental Biology and Medicine·Megan T Zangara, Christine McDonald
Sep 27, 2020·Molecular Nutrition & Food Research·Bianca F LeonardiAline R Zimmer
Dec 22, 2020·Frontiers in Microbiology·Miguel Villoria RecioMarianne Halberg Larsen
Aug 27, 2019·European Journal of Pharmacology·Rubiya KhursheedKamal Dua
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yujie WangYuguang Du
Dec 13, 2019·Journal of Agricultural and Food Chemistry·Yongjian LiuZhengquan Su
Aug 23, 2021·The Journal of Nutritional Biochemistry·Yifei BianBingkun Zhang
Nov 18, 2021·Journal of the Science of Food and Agriculture·Jianjun YangJunhua Jin

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

PICRUSt ( Phylogenetic Investigation of Communities by Reconst...
UCLUST
COS
GraphPad
GraphPad Prism
Quantitative Insights Into Microbial Ecology ( QIIME )
PICRUSt
Image J2x

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