Chitin/silk fibroin/TiO2 bio-nanocomposite as a biocompatible wound dressing bandage with strong antimicrobial activity

International Journal of Biological Macromolecules
Mojtaba Ghanbari MehrabaniHossein Samadi Kafil

Abstract

Interconnected microporous biodegradable and biocompatible chitin/silk fibroin/TiO2 nanocomposite wound dressing with high antibacterial, blood clotting and mechanical strength properties were synthesized using freeze-drying method. The prepared nanocomposite dressings were characterized using SEM, FTIR, and XRD analysis. The prepared nanocomposite dressings showed high porosity above 90% with well-defined interconnected porous construction. Swelling and water uptake of the dressing were 93%, which is great for wound dressing applications. Haemostatic potential of the prepared dressings was studied and the results proved the higher blood clotting ability of the nanocomposites compared to pure components and commercially available products. Besides, cell viability, attachment and proliferation by MTT assay and DAPI staining on HFFF2 cell as a Human Caucasian Foetal Foreskin Fibroblast proved the cytocompatibility nature of the nanocomposite scaffolds with well improved proliferation and cell attachment. To determine the antimicrobial efficiencies, both disc diffusion method and colony counts were performed and results imply that nanocomposite scaffolds have high antimicrobial activity and could successfully inhibit the growth of...Continue Reading

Citations

Oct 17, 2019·Pharmaceutics·Patricia Hissae Yassue-CordeiroClassius Ferreira da Silva
Feb 2, 2019·Scientific Reports·Cheirmadurai KalirajanThanikaivelan Palanisamy
Jan 23, 2020·Marine Drugs·Mitchell JonesAlexander Bismarck
Jun 21, 2020·International Journal of Molecular Sciences·Vanessa P SantosGalba Maria de Campos-Takaki
Nov 5, 2019·Advanced Drug Delivery Reviews·Mazaher GholipourmalekabadiSubhas C Kundu
Jan 1, 2020·Carbohydrate Polymers·Mahdi RahimiHossein Samadi Kafil
Mar 2, 2021·APL Bioengineering·Zheng PanDecheng Wu
Feb 20, 2021·International Journal of Biological Macromolecules·Mohammad MesgariAmirhossein Sahebkar
Jul 1, 2020·International Journal of Biological Macromolecules·Elaheh FakhriHossein Samadi Kafil
Jun 8, 2021·Advances in Colloid and Interface Science·Małgorzata JurakKlaudia Szafran
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beatriz G BernardesAna Leite Oliveira
Jul 3, 2021·Polymers·Sibusiso Alven, Blessing A Aderibigbe
Aug 18, 2021·International Journal of Biological Macromolecules·Hadis FathizadehHossein Samadi Kafil
Jan 20, 2021·ACS Biomaterials Science & Engineering·Suna FanYaopeng Zhang

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