Chitooligosaccharides inhibit activation and expression of matrix metalloproteinase-2 in human dermal fibroblasts

FEBS Letters
Moon-Moo Kim, Se-Kwon Kim

Abstract

Recently, much attention has been given to chitosan and its hydrolyzed products due to their diverse biological activities. For the first time here we report the inhibitory effect of chitooligosaccharides (COS) on activation and expression of matrix metalloproteinase-2 (MMP-2) in primary human dermal fibroblasts (HDFs). COS with 3-5 kDa exhibited the highest inhibitory effect on MMP-2 activity in HDFs assessed by gelatin zymography. Interestingly, protein expression of MMP-2 was also inhibited by COS with same molecular weight. This inhibition was caused by the decrease of the gene expression and transcriptional activity of MMP-2. Furthermore, it was found that COS repressed the gene expression of c-fos, a part of AP-1 transcription factor. These results suggest that COS may play an important role in the prevention and treatment of MMP-2 mediated several health problems such as metastasis and wrinkle formation.

References

May 1, 1993·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·S NaruoS Kagawa
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R NelsonL M Matrisian
Apr 6, 2002·Journal of Cancer Research and Clinical Oncology·E HrabecZ Hrabec
Jul 16, 2005·Experimental Lung Research·Subhadeep Chakrabarti, Kamala D Patel

❮ Previous
Next ❯

Citations

Sep 29, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Byul-Nim AhnSe-Kwon Kim
Apr 24, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hong YangXiaonong Zhang
Jan 5, 2011·Biochemistry Research International·Noel Vinay Thomas, Se-Kwon Kim
Jan 1, 2010·International Journal of Molecular Sciences·Bae Keun Park, Moon-Moo Kim
May 19, 2010·Marine Drugs·Ramjee PallelaSe-Kwon Kim
Aug 18, 2010·Marine Drugs·Ratih Pangestuti, Se-Kwon Kim
Dec 1, 2010·Marine Drugs·Ira Bhatnagar, Se-Kwon Kim
Jul 30, 2009·Expert Opinion on Drug Delivery·Maria Cristina BonferoniCarla Caramella
May 12, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kun-Te ShenYing-Jan Wang
Apr 15, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Subo WangXianjun Qu
Nov 7, 2012·Photodermatology, Photoimmunology & Photomedicine·Jung-Ae KimSe-Kwon Kim
Mar 18, 2010·Acta Physiologica Hungarica·Simona ClichiciA Muresan
Jun 11, 2016·Molecular Pharmaceutics·Naba ElsaidSatyanarayana Somavarapu
May 18, 2016·Experimental Biology and Medicine·Rebecca A Hortensius, Brendan Ac Harley
Jun 20, 2019·Expert Opinion on Drug Delivery·Barbara ViganiFranca Ferrari
Dec 12, 2012·Current Opinion in Allergy and Clinical Immunology·Ahmed BassiouniPeter-John Wormald
Mar 12, 2020·Brazilian Dental Journal·Kellin PivattoAlvaro Henrique Borges

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.