Chitosan: a propitious biopolymer for drug delivery

Current Drug Delivery
Dibyangana S DuttaguptaVilasrao J Kadam

Abstract

Scientists have always been interested in the use of natural polymers for drug delivery. Chitosan, being a natural cationic polysaccharide has received a great deal of attention in the past few years. It is obtained by deacetylation of chitin and is regarded as the second most ubiquitous polymer subsequent to cellulose on earth. Unlike other natural polymers, the cationic charge possessed by chitosan is accountable for imparting interesting physical and chemical properties. Chitosan has been widely exploited for its mucoadhesive character, permeation enhancing properties and controlled release of drugs. Moreover it's non-toxic, biocompatible and biodegradable properties make it a good candidate for novel drug delivery system. This review provides an insight on various chitosan based formulations for drug delivery. Some of the current applications of chitosan in areas like ophthalmic, nasal, buccal, sublingual, gastro-retentive, pulmonary, transdermal, colon-specific and vaginal drug delivery have been discussed. In addition, active targeting of drugs to tumor cells using chitosan has been described. Lastly a brief section covering the safety aspects of chitosan has also been reviewed.

Citations

Jan 16, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Monika KauravRavi Shankar Pandey
Aug 12, 2015·International Journal of Pharmaceutics·Naila El KechaiAmélie Bochot
Apr 24, 2016·Carbohydrate Polymers·Jing WangZheng-Wu Bai
Jul 10, 2016·International Journal of Biological Macromolecules·A M OmerN Koseva
Jan 18, 2017·International Journal of Biological Macromolecules·Seema Patel, Arun Goyal
Jun 21, 2017·Biomaterials Science·Qin Wang, Xun Sun
Jan 3, 2018·Nanomaterials·Sylvie SkalickovaRene Kizek
Sep 29, 2017·Drug Development and Industrial Pharmacy·Abeer S HassanGamal El-Din A El-Gindy
Jul 3, 2019·International Journal of Molecular Sciences·Dae Gun ChoiMin Suk Shim
Aug 29, 2018·Nanomaterials·Juan I BussioJosé Vicente González-Aramundiz
Apr 9, 2020·Frontiers in Bioengineering and Biotechnology·Courtney R LynchViness Pillay
Dec 6, 2018·International Journal of Molecular Sciences·Daniela ChirioMarina Gallarate
Mar 6, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Wentao YangYanping Xie
Feb 22, 2021·International Journal of Biological Macromolecules·Arezou Baharlou HourehMohammad Hossein Nasr-Esfahani
Nov 8, 2017·Carbohydrate Polymers·Andrea AmatoIolanda Francolini
Jul 24, 2018··Alessandro GoriStefano Serra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Radi Hejazi, Mansoor Amiji
Expert Opinion on Drug Delivery
Arvind Gulbake, Sanjay K Jain
Archivos de la Sociedad Española de Oftalmología
Y Ogura
© 2021 Meta ULC. All rights reserved