Chitosan-aluminum monostearate composite sponge dressing containing asiaticoside for wound healing and angiogenesis promotion in chronic wound

Materials Science & Engineering. C, Materials for Biological Applications
Thawatchai PhaechamudYasuhiko Tabata

Abstract

There are many factors that delay healing in chronic wounds including lowering level of growth factors and increasing exudate level comprising high amount of tissue destructive enzymes. Asiaticoside possesses interesting wound healing and angiogenic activities that are employed to stimulate tissue regeneration in wound healing application. This study attempted to develop chitosan-aluminum monostearate (Alst) composite sponge containing asiaticoside for use as an absorbent medical dressing in chronic wound. N-methyl-2-pyrrolidone (NMP) was used to enhance homogeneity of asiaticoside in the polymer composite matrix. The sponge dressings were prepared by lyophilization and dehydrothermal treatment (DHT). Functional group interaction, crystallinity, and morphology of the prepared sponges were investigated using FT-IR, PXRD, and SEM, respectively. Physicochemical properties, porosity, hydrophilic/hydrophobic properties and mechanical property, were evaluated. Wound dressing properties, water vapor transmission rate (WVTR), fluid absorbency, oxygen permeation (OP), and bio-adhesive property, were investigated. In vitro asiaticoside release study was conducted using immersion method. Cytotoxicity was studied in normal human dermal fib...Continue Reading

References

Jan 30, 2010·Skin Pharmacology and Physiology·C WiegandU-C Hipler
Nov 22, 2011·Nanotechnology·Rituparna Sinha RoyShiladitya Sengupta
Jan 18, 2012·International Wound Journal·India R SweeneyGraham Collyer
Apr 17, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Piyush Koria
Sep 4, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jeong-Hyun LeeJong-Chul Park
Feb 15, 2014·Advances in Wound Care·Mateusz S Wietecha, Luisa A Dipietro
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Kotchamon Yodkhum, Thawatchai Phaechamud

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Citations

Sep 11, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chen-Zhen ZhangLi-Hua Peng
Jul 2, 2019·The International Journal of Lower Extremity Wounds·Fahimeh RezaieHojjat Naderi-Meshkin
May 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guixue XiaXiguang Chen
Mar 10, 2017·Journal of Biomaterials Science. Polymer Edition·Qin ZouYubao Li
Nov 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Julianderson CarmoEmiliano Barreto
Jan 25, 2021·International Journal of Pharmaceutics·Muhammad Maaz ArifMuhammad Arif Butt
Sep 30, 2018·Advanced Drug Delivery Reviews·Austin P VeithAaron B Baker
Jun 3, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Meng-Na LiYa-Ping Guo

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