Chitosan ascorbate: a chitosan salt with improved penetration enhancement properties

Pharmaceutical Development and Technology
Silvia RossiCarla Caramella

Abstract

The aim of the present work was to investigate if chitosan salification with ascorbic acid could produce an increase in chitosan penetration enhancement properties towards buccal mucosa and intestinal Caco-2 cell monolayer. Three different chitosan grades were considered. Chitosan hydrochloride and lactate were used as references. Fluorescein isothiocyanate-dextran (FD4), a hydrophilic high MW molecule, was employed as model penetrant. Chitosan ascorbate showed better penetration enhancement properties towards both buccal porcine mucosa and Caco-2 cell monolayer with respect to hydrochloride and lactate salts. Cytotoxicity of chitosan ascorbate assessed on Caco-2 cells was comparable with those of chitosan hydrochloride and lactate.

References

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Citations

May 12, 2011·AAPS PharmSciTech·Mirna Fernández CerveraJouko Yliruusi
Nov 3, 2010·Journal of Microencapsulation·Giuseppina SandriCarla Caramella
Dec 4, 2010·Drug Development and Industrial Pharmacy·Chidambaram SoundrapandianSomeswar Datta
Jul 30, 2009·Expert Opinion on Drug Delivery·Maria Cristina BonferoniCarla Caramella
Apr 1, 2011·Journal of Pharmaceutical Sciences·Elisabetta GaviniAlessandro Dalpiaz
Nov 17, 2010·Pharmaceutical Development and Technology·Silvia RossiCarla Caramella
Sep 6, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Chidambaram SoundrapandianDebebrata Basu
Oct 27, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S RossiC Caramella
Jan 24, 2009·Journal of Pharmaceutical and Biomedical Analysis·János BajdikKlára Pintye-Hódi
Aug 17, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eleonora DelleraCarla Caramella
Feb 16, 2019·Journal of Agricultural and Food Chemistry·Wenqiang TanZhanyong Guo

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