Chitosan-Based Hydrogel Microparticles for Treatment of Carcinoma in a Rabbit VX2 Liver Tumor Model

Journal of Vascular and Interventional Radiology : JVIR
Hyosook HwangHwan-Jeong Jeong

Abstract

To investigate potential of chitosan hydrogel microparticles (CHI) for treatment of VX2 carcinoma. Two weeks after liver VX2 implantation, contrast-enhanced computerized tomographic scanning was conducted. Rabbits (n = 2) with successful tumor growth were treated with different sizes of 99mTc-labeled CHI (60-80 μm and 100-120 μm) via intra-arterial hepatic catheterization. Liver distribution of 99mTc-labeled CHI was determined by means of autoradiography, a radiation-based photographic technique. In the next part of this study, therapeutic effectiveness was examined with the use of CHI with the size range of 60-80 μm (n = 11). Tumor growth response and levels of blood liver enzymes were studied at baseline and 1 and 2 weeks after CHI treatment. Successful tumor growth was confirmed in all rabbits (24/24). Intrahepatic CHI with the size range of 60-80 μm resulted in liver localization in more close proximity to tumor nodule versus 100-120 μm. Baseline tumor volume was 1,909 ± 575 mm3 in animals receiving CHI versus 1,831 ± 249 mm3 in control animals (P = .342). In control animals, tumor volume markedly increased by 1,544 ± 512% at 2 weeks after sham operation versus baseline. In animals receiving CHI, tumor volume remained relat...Continue Reading

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