Chitosan-based luminescent/magnetic hybrid nanogels for insulin delivery, cell imaging, and antidiabetic research of dietary supplements

International Journal of Pharmaceutics
Jian-Min ShenHai-Xia Zhang

Abstract

In this work, the chitosan-based luminescent/magnetic (CLM) nanomaterials were synthesized by direct gelation of chitosan, CdTe and superparamagnetic iron oxide into the hybrid nanogels. The morphology, sizes and properties of the nanogels prepared with different chitosan/QD/MNP ratios and under different processing parameters were researched. Fluorescence microscopy, FTIR spectra and TEM images confirmed the success of the preparation of the CLM hybrid nanogels. Spherical CLM hybrid nanogels with appropriate average sizes (<160 nm) were used for insulin loading. The actual loading amount of insulin was approximately 40.1mg/g. Human normal hepatocytes L02 cell line was used to explore the effects of additives, such as mangiferin (MF), (-)-epigallocatechin gallate (EGCG), and (-)-epicatechin gallate (ECG) on the insulin-receptor-mediated cellular uptake using insulin-loaded CLM (ICLM) hybrid nanogels. Above 80% of viability of L02 cells were watched at a nanogels concentration of 500 μg/mL whatever the additives existed or not. The study discovered that the fluorescent signals of the ICLM hybrid nanogels in L02 cells were more intense in the presence of MF, EGCG and ECG in medium than in the absence of these components, respecti...Continue Reading

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Citations

Aug 5, 2014·Therapeutic Delivery·Lærke ArnfastStefania Baldursdottir
Feb 5, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jian-Min ShenFeng Yue
Jul 9, 2013·International Journal of Pharmaceutics·Alexandru Mihai GrumezescuCarmen Mariana Chifiriuc
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Jul 3, 2013·ACS Applied Materials & Interfaces·Jian-Min ShenShuang Xu
Sep 21, 2021·Journal of Biomolecular Structure & Dynamics·Shruti G BhatkalkarShilpee Sachar

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