Chitosan based micro- and nanoparticles for colon-targeted delivery of vancomycin prepared by alternative processing methods

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
T CerchiaraB Luppi

Abstract

The aim of this work was to prepare chitosan (CH) based particulate formulations for colon delivery of vancomycin (VM). Chitosan microparticles (MPs) and nanoparticles (NPs) loaded with VM were prepared using different CH/tripolyphosphate (TPP) molar ratios and different technological processes. In particular, nanoparticles were prepared by ionic gelation and freeze-drying to recover these particles, or, alternatively, by spray-drying method. Microparticles were prepared using a different spray-dryer. Micro- and nanoparticles were characterized in terms of size distributions by photon correlation spectroscopy (PCS), while encapsulation and drug loading efficiencies were studied using a dialysis method. Fourier Transform Infrared Spectroscopy (FT-IR) was employed to determine the surface composition of the micro- and nanoparticles respectively, and the morphologies of the developed systems were studied by scanning electron microscopy (SEM). Water uptake as well as drug release profiles were also measured. Antibacterial activity against Staphylococcus aureus, a Gram-positive model strain, was evaluated. FT-IR results suggested an electrostatic interaction between VM and CH/TPP particles. Moreover, the particles were found to hold...Continue Reading

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Citations

Oct 28, 2015·Journal of Pharmaceutical Sciences·Angela AbruzzoBarbara Luppi
Jul 7, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Estefanía Blanco-GarcíaAsteria Luzardo-Álvarez
Oct 13, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vinicius B V MacielTelma T Franco
Jul 17, 2019·AAPS PharmSciTech·Giovana Maria Fioramonti CalixtoCarla Raquel Fontana
Jul 26, 2017·Scientific Reports·Hebatallah B MohamedMahmoud Elsabahy
Apr 5, 2020·Nanomaterials·Maria C TeixeiraEliana B Souto
Mar 27, 2020·Frontiers in Bioengineering and Biotechnology·Cíntia MarquesGerrit Borchard
Nov 22, 2017·Pharmaceutics·Munawar A MohammedEllen K Wasan
Jun 20, 2020·Microbial Cell Factories·Priscilla Romina De GregorioBeatrice Vitali
Jul 1, 2020·Expert Opinion on Drug Delivery·Annalisa Bianchera, Ruggero Bettini
Sep 14, 2019·Plant Physiology and Biochemistry : PPB·Silvana Lorena ColmanClaudia Anahí Casalongué
Sep 11, 2020·International Journal of Pharmaceutics·A JadidiL Tayebi
Apr 27, 2021·Pharmaceutical Development and Technology·Sara BahrainianKambiz Gilani
Sep 5, 2018·Carbohydrate Polymers·Sergio Martin-SaldañaAlberto Antonio Chevalier
May 17, 2021·International Journal of Pharmaceutics·Vivek VermaLuis Padrela
Jul 13, 2021·International Journal of Pharmaceutics·A AbruzzoF Bigucci
Sep 23, 2021·Assay and Drug Development Technologies·A Alper Öztürk, Cordin Arpagaus

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