Chitosan-based zinc oxide nanoparticle for enhanced anticancer effect in cervical cancer: A physicochemical and biological perspective

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Henghui Wu, Juxin Zhang

Abstract

In this study, chitosan-assembled zinc oxide nanoparticle (CZNP) was successfully prepared for evaluated for its anticancer efficacy against cervical cancer cells. The CZNP particles were nanosized and spherical in shape. The zinc oxide nanoparticle (ZNP) and CZNP showed significant cytotoxicity in cervical cancer cells in a concentration-dependent manner. Results showed that the enhanced cytotoxicity was mainly attributed to the reactive oxygen species (ROS) generation in the cancer cells. The apoptosis assay further revealed that apoptosis was the main reason behind the cell killing effect of the zinc oxide nanoparticles. The apoptosis was further confirmed by the nuclear chromatin assay. Live dead assay showed increased red fluorescent cell for CZNP treated cancer cells. Overall, metal oxide present in nanoparticulate dimensions will be advantageous in imparting the cytotoxicity to cervical cancer cell.

References

Jan 25, 2007·British Journal of Pharmacology·C MedinaM W Radomski
Sep 9, 2008·Journal of Photochemistry and Photobiology. B, Biology·Dadong GuoBaoan Chen
Nov 18, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Suresh Vir Singh Rana
Feb 25, 2009·ACS Nano·P V AshaRaniSuresh Valiyaveettil
Nov 3, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Mariappan PremanathanGovindasamy Manivannan
Jan 13, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Li XuZan-Hong Wang

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Citations

Mar 19, 2020·Critical Reviews in Toxicology·S Keerthana, A Kumar
Jul 28, 2020·Pharmaceutics·Anastasia DetsiPanagiotis Zoumpoulakis
Jun 20, 2018·International Journal of Molecular Sciences·Sreekar B Marpu, Erin N Benton
Nov 12, 2020·Materials·Rayssa de Sousa VictorRomualdo Rodrigues Menezes
Jun 3, 2021·International Journal of Molecular Sciences·Natalia WrońskaKatarzyna Lisowska
Jun 27, 2020·Current Pharmaceutical Design·Abimanyu Sugumaran, Vishali Mathialagan
Sep 11, 2021·International Journal of Molecular Sciences·Veronika Mikušová, Peter Mikuš

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Methods Mentioned

BETA
dynamic
transmission electron microscopy
dynamic light scattering
FACS

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