Chitosan-co-Hyaluronic acid porous cryogels and their application in tissue engineering

International Journal of Biological Macromolecules
Tuğçe KutlusoySerap Erdem Kuruca

Abstract

In this work, the usability of chitosan-co-hyaluronic acid cryogels as a tissue-engineering scaffold was investigated. Chitosan-co-hyaluronic acid cryogels were synthesized at subzero temperature. Cryogels which were composed of various compositions of chitosan and hyaluronic acid (0, 10, 20, 30 and 50wt% hyaluronic acid) was prepared. Morphological studies showed that the macroporous cryogels have been developed with 90-95% porosity. Particularly, the mechanical and biomaterial property of pure chitosan was improved by making copolymer with hyaluronic acid in different concentration. The MTT cell viability results demonstrated that the cryogels have no significant cytotoxicity effect on 3T3 fibroblast and SAOS-2 cells.

References

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Citations

Jan 19, 2019·Current Pharmaceutical Design·Chahinez HouacineKamalinder K Singh
Jun 23, 2020·Biomedical Materials·Duarte Nuno CarvalhoTiago H Silva
Aug 9, 2018·Materials·Mahboobeh RezaeeyazdiSidi A Bencherif
May 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·M RabykM Hruby
Apr 10, 2019·Polymers·Sanjay TiwariPratap Bahadur
Feb 2, 2021·Journal of Orthopaedic Translation·Sida LiaoShibi Lu
Mar 6, 2021·International Journal of Biological Macromolecules·F Rafiee, M Rezaee
Apr 3, 2021·Biomaterials Research·Mallinath S BirajdarHansoo Park
May 4, 2021·MRS Communications·Joseph Rey H Sta AguedaRigoberto C Advincula
Dec 5, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Chutamart Pitakchatwong, Suwabun Chirachanchai
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Qianwen YangYichun Liu

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