Chitosan-coated antifungal formulations for nebulisation

The Journal of Pharmacy and Pharmacology
Yacoub Y AlbasarahKevin M G Taylor

Abstract

The aim of this study was to produce and characterise amphotericin B (AmB) containing chitosan-coated liposomes, and to determine their delivery from an air-jet nebuliser. Soya phosphatidylcholine : AmB (100 : 1) multilamellar vesicles were generated by dispersing ethanol-based proliposomes with 0.9% sodium chloride or different concentrations of chitosan chloride. These liposomes were compared with vesicles produced by the film hydration method and micelles. AmB loading, particle size, zeta potential and antifungal activity were determined for formulations, which were delivered into a two-stage impinger using a jet nebuliser. AmB incorporation was highest for liposomes produced from proliposomes and was greatest (approximately 80% loading) in chitosan-coated formulations. Following nebulisation, approximately 60% of the AmB was deposited in the lower stage of the two-stage impinger for liposomal formulations, for which the mean liposome size was reduced. Although AmB loading in deoxycholate micellar formulations was high (99%), a smaller dose of AmB was delivered to the lower stage of the two-stage impinger compared to chitosan-coated liposomes generated from proliposomes. Chitosan-coated and uncoated liposomes loaded with AmB...Continue Reading

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Citations

May 17, 2011·Virology Journal·Nora H Rosas-MurrietaIrma Herrera-Camacho
Mar 27, 2015·Nature Communications·Maximilian W Popp, Lynne E Maquat
Sep 28, 2020·Experimental Parasitology·DongLing NiuWanYu Zhang
Apr 24, 2012·Chemical Reviews·Reem SmoumMorris Srebnik

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