Chitosan-coated C-phycocyanin Liposome for Extending the Neuroprotective Time Window Against Ischemic Brain Stroke

Current Pharmaceutical Design
Goo Yong ChungHwa Sung Shin

Abstract

The time window for neuroprotection during ischemic brain stroke is short, and hence, development of neuroprotectants is critical to extend this time window. This study sought to verify if muco-adhesive chitosan coating improves the neuroprotective potential of the pre-proven C-Phycocyanin-pertaining liposome (C-Pc liposome). The use of chitosan-coated liposomes extended the neuroprotective time window by 6 h after occlusion, and further improved the neuroprotection efficiency of the C-Pc liposome in a rat Middle Cerebral Artery Occlusion (MCAO) model. Beneficial changes in mRNA expressions of antioxidants, inflammatory cytokines and glia scar proteoglycans were evident in the C-Pc liposomes. In addition, in the cultured astrocytes, the chitosan- coated C-Pc liposome expressed anti-oxidative activity without cytotoxicity.

Citations

Nov 27, 2018·Journal of Industrial Microbiology & Biotechnology·Linquan BaiEung-Soo Kim
Jan 25, 2020·Drug Discovery Today·Saeideh NozohouriThomas J Abbruscato
Feb 21, 2021·Chemistry and Physics of Lipids·Alessandro Oliveira de Moraes NogueiraVânia Rodrigues de Lima

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