Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin

Drug Delivery and Translational Research
Pedro FonteBruno Sarmento

Abstract

The development of alternative routes to the conventional subcutaneous administration of insulin is expected to provide an important advance in the management of diabetes. The aim of this work was to produce and characterize chitosan-coated Witepsol 85E solid lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal carriers for oral administration. SLN were prepared by a modified solvent emulsification-evaporation method based on a water/oil/water double emulsion followed by chitosan adsorption to SLN surface. Optimized chitosan-coated SLN presented a mean particle size around 450 nm and were positively charged, indicating synergic properties for intestinal absorption. Higher extent of insulin permeation was observed for SLN and chitosan-coated SLN in a Caco-2 cell monolayer model. When comparing both SLN formulations, chitosan coating was shown to provide higher insulin permeation. Also, similar effects were also observed using a Caco-2/HT29 monolayer model, which more closely resemble the intestinal membrane, thus indicating that the mucoadhesive properties and permeation enhancement effect of chitosan may contribute significantly to the enhanced insulin permeation. After oral administrat...Continue Reading

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