Chitosan coated vancomycin hydrochloride liposomes: Characterizations and evaluation

International Journal of Pharmaceutics
Zhenlei YangGuihua Huang

Abstract

The present work evaluated the feasibility of chitosan coated liposomes (c-Lips) for the intravenous delivery of vancomycin hydrochloride (VANH), a water-soluble antibiotic for the treatment of gram-positive bacterial infections like osteomyelitis, arthritis, endocarditis, pneumonia, etc. The objective of this research was to develop a suitable drug delivery system in vivo which could improve therapeutic efficacy and decrease side effects especially nephrotoxicity. Firstly, the vancomycin hydrochloride liposomes (VANH-Lips) were prepared by modified reverse phase evaporation method, then the chitosan wrapped vancomycin hydrochloride liposomes (c-VANH-Lips) nanosuspension was formulated by the method of electrostatic deposition. Based on the optimized results of single-factor screening experiment, the c-VANH-Lips were found to be relatively uniform in size (220.40 ± 3.56 nm) with a narrow polydispersity index (PI) (0.21 ± 0.03) and a positive zeta potential (25.7 ± 1.12 mV). The average drug entrapment efficiency (EE) and drug loading (DL) were 32.65 ± 0.59% and 2.18 ± 0.04%, respectively. The in vitro release profile of c-VANH-Lips possessed a sustained release Characterization and the release behavior was in accordance with th...Continue Reading

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Citations

May 25, 2016·Reproduction in Domestic Animals = Zuchthygiene·V R Kasimanickam, M M Buhr
Oct 25, 2016·International Journal of Pharmaceutics·Paula Santos NunesAdriano Antunes de Souza Araújo
Sep 19, 2017·Journal of Liposome Research·Zhenlei YangGuihua Huang
Jun 14, 2016·Therapeutic Advances in Endocrinology and Metabolism·Oluwatoyin Bamgbola
Jan 21, 2020·Pharmacotherapy·Anne M MasichMathangi Gopalakrishnan
Jan 1, 2020·Current Protein & Peptide Science·Sk Abdul Mohid, Anirban Bhunia
Jun 6, 2018·Frontiers in Microbiology·Lubhandwa S BiswaroOctavio L Franco
Jun 10, 2020·Drug Delivery and Translational Research·Magda FerreiraMaria Manuela Gaspar
Jan 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammed O AlshraimMohamed M Badran
Apr 23, 2020·Advances in Wound Care·Yayoi KawanoViorica Patrulea
Dec 28, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Adane S NigatuAshish Ranjan
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Matthew DraytonSuzana K Straus
Mar 27, 2020·ACS Infectious Diseases·Azucena Gonzalez Gomez, Zeinab Hosseinidoust
Feb 25, 2021·International Journal of Biological Macromolecules·Melappa GovindappaArivalagan Pugazhendhi
Mar 30, 2016·Colloids and Surfaces. B, Biointerfaces·Shengli WanJingqing Zhang
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Syed Sarim ImamBjad K Almutairy
Jul 27, 2021·Advanced Materials Technologies·Jill ZiesmerGeorgios A Sotiriou
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