Chitosan-Covered Pd@Pt Core-Shell Nanocubes for Direct Electron Transfer in Electrochemical Enzymatic Glucose Biosensor

ACS Omega
Siva Kumar KrishnanM Meyyappan

Abstract

Development of biosensors with high sensitivity, high spatial resolution, and low cost has received significant attention for their applications in medical diagnosis, diabetes management, and environment-monitoring. However, achieving a direct electrical contact between redox enzymes and electrode surfaces and enhancing the operational stability still remain as challenges. Inorganic metal nanocrystals (NCs) with precisely controlled shape and surface structure engineered with an appropriate organic coating can help overcome the challenges associated with their stability and aggregation for practical biosensor applications. Herein, we describe a facile, room-temperature, seed-mediated solution-phase route to synthesize monodisperse Pd@Pt core-shell nanocubes with subnanometer-thick platinum (Pt) shells. The enzyme electrode consisting of Pd@Pt core-shell NCs was first covered with a chitosan (CS) polymer and then glucose oxidase (GOx) immobilized by a covalent linkage to the CS. This polymer permits covalent immobilization through active amino (-NH) side groups to improve the stability and preserve the biocatalytic functions while the Pd@Pt NCs facilitate enhanced direct electron transfer (DET) in the biosensor. The resultant bi...Continue Reading

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Citations

May 30, 2019·Nanoscale·Quan-Lan LiaoWei-Hua Huang
Sep 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Siva Kumar-KrishnanM Meyyappan
Dec 5, 2019·Polymers·Dipali R Bagal-Kestwal, Been-Huang Chiang
Jul 28, 2020·International Journal of Molecular Sciences·Kim-Hung HuynhBong-Hyun Jun
Feb 2, 2018·Advanced Healthcare Materials·Arti VashistMadhavan Nair
Aug 17, 2019·Current Medicinal Chemistry·Javad TavakoliYouhong Tang
Oct 31, 2020·Sensors·Fanny J González-FuentesMiriam Estevez
Feb 20, 2018·The Journal of Physical Chemistry. B·Rajeswari PonnusamyChandra Sekhar Rout
Oct 15, 2020·Chemical Reviews·Hui ChenShelley D Minteer

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Methods Mentioned

BETA
biosensing
biosensors
biosensor
transmission electron microscopy
X-ray
dynamic light scattering

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