Chitosan-EDTA new combination is a promising candidate for treatment of bacterial and fungal infections

Current Microbiology
Amany A El-Sharif, Mohamed H M Hussain

Abstract

Chitosan is an attractive preparation widely used as a pharmaceutical excipient. This study aimed to evaluate the antimicrobial activities of chitosan derivatives, EDTA, and the newly developed chitosan-EDTA combination against Gram-negative and Gram-positive bacteria as well as Candida albicans. Antimicrobial activity was studied. Both minimal Inhibitory Concentrations (MIC) and minimal biocidal concentrations (MBC) were determined. Chitosan acetic acid recorded lower MIC values against Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans than those exhibited by EDTA. EDTA failed to have inhibitory activity against Enterococcus faecalis as well as MBC against any of the studied microorganisms. Chitosan acetic acid's MBC were recorded to all examined species. Checkerboard assay results indicated a synergistic antimicrobial activity of the new combination against Staphylococcus aureus and an additive effect against other microorganisms. Moreover, a short microbial exposure to chitosan-EDTA (20-30 min) caused complete eradication. Due to the continuous emergence of resistant strains, there is an urgent need to discover new antimicrobial agents. Our findings suggest the use o...Continue Reading

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Citations

May 18, 2013·International Journal of Pharmaceutics·Natthan CharernsriwilaiwatPraneet Opanasopit
Dec 17, 2014·Carbohydrate Polymers·Wipada SamprasitPraneet Opanasopit
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Jan 27, 2021·Drug Delivery and Translational Research·Qingye MengFu-Jian Xu

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