Chitosan-folate decorated carbon nanotubes for site specific lung cancer delivery

Materials Science & Engineering. C, Materials for Biological Applications
Rahul Pratap SinghMadaswamy S Muthu

Abstract

The aim of this work was to formulate chitosan-folate conjugated multi-walled carbon nanotubes for the lung cancer targeted delivery of docetaxel. The chitosan-folate conjugate was synthesized and the conjugation was confirmed by Fourier transform infrared spectroscopy. The multi-walled carbon nanotubes were characterized for their particle size, polydispersity, zeta potential, surface morphology, drug encapsulation efficiency and in vitro release study. The in vitro cellular uptake, cytotoxicity, and cell cycle analysis of the docetaxel/coumarin-6 loaded multi-walled carbon nanotubes were carried out to compare the effectiveness of the formulations. The biocompatibility and safety of chitosan-folate conjugated multi-walled carbon nanotubes was analyzed by lung histopathology in comparison with marketed docetaxel formulation (Docel™) and acylated multi-walled carbon nanotubes. The cellular internalization study shown that the chitosan-folate conjugated multi-walled carbon nanotubes could be easily internalized into the lung cancer cells through a folate receptor-mediated endocytic pathway. The IC50 values exhibited that chitosan-folate conjugated multi-walled carbon nanotubes could be 89-fold more effective than Docel™ in human...Continue Reading

Citations

Nov 13, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Wen LiYuanyan Liu
Mar 17, 2020·Drug Delivery and Translational Research·Arpit BhargavaPradyumna Kumar Mishra
May 10, 2020·Current Drug Delivery·Biman Kumar Panigrahi, Amit Kumar Nayak
Nov 12, 2020·Materials·Rayssa de Sousa VictorRomualdo Rodrigues Menezes
Jan 2, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hualing XiePing Shao
Dec 19, 2020·International Journal of Biological Macromolecules·Sheersha Pramanik, Vaishnavi Sali
Feb 11, 2021·Journal of Drug Targeting·Mohaddeseh SajjadiSiavash Iravani
Mar 11, 2021·International Journal of Nanomedicine·Hossein ZareEbrahim Mostafavi
Jun 16, 2021·Colloids and Surfaces. B, Biointerfaces·Huixian YanGuangxi Zhai
Jul 7, 2021·Analytical Methods : Advancing Methods and Applications·Jiaxin ZhangLongshan Zhao
May 14, 2020·Mini Reviews in Medicinal Chemistry·Katarzyna PieklarzZofia Modrzejewska
Sep 11, 2021·International Journal of Molecular Sciences·Veronika Mikušová, Peter Mikuš

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