Chitosan gel-embedded moxifloxacin niosomes: An efficient antimicrobial hybrid system for burn infection

International Journal of Biological Macromolecules
Shohreh SohrabiSimin Dadashzadeh

Abstract

The purpose of this study was to prepare and characterize a hybrid system of moxifloxacin loaded niosomes incorporated into chitosan gel as a potential carrier for topical antimicrobial delivery. The prepared system was characterized regarding entrapment efficiency, particle size, zeta potential, in vitro drug release kinetics, morphology, FTIR analysis, bioadhesive strength and rheological behavior. The effect of different formulation parameters (surfactant type, surfactant to drug ratio, cholesterol percentage and loading methodology) on moxifloxacin entrapment and drug release was evaluated. The antibacterial effectiveness of various formulations was also assessed by measuring the minimal inhibitory concentrations, minimal bactericidal concentrations and agar diffusion assay using Pseudomonas aeruginosa and Staphylococcus aureus as model pathogens. The optimized niosomal formulation showed 73% drug entrapment, 47% drug release in 8h and was ∼290 nm in particle diameter and negatively charged (ζ∼-23 mV). The gel-embedded niosomes exhibited pseudo-plastic flow behavior and more sustained drug release profile compared to niosomes. The niosomal formulation of moxifloxacin was the most efficient system against P. aeruginosa, whil...Continue Reading

References

Jan 1, 1989·European Journal of Nuclear Medicine·I Ogihara-Umeda, S Kojima
Mar 7, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A LippacherK Mäder
Apr 4, 2002·International Journal of Food Microbiology·Hong Kyoon NoSamuel P Meyers
Nov 29, 2002·Drug Development and Industrial Pharmacy·Kavita VermaniLourens J D Zaneveld
Nov 13, 2003·Methods in Enzymology·Ewoud C van Winden
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C-J SoussyP Courvalin
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Dan Peer, Rimona Margalit
Apr 6, 2004·Critical Care Nursing Clinics of North America·Shari Honari
Apr 15, 2006·Clinical Microbiology Reviews·Deirdre ChurchRobert Lindsay
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Veronica WassermanYechezkel Barenholz
Sep 11, 2007·Infectious Disease Clinics of North America·B R Sharma
May 5, 2009·International Journal of Pharmaceutics·Inbar Elron-GrossRimona Margalit
Jun 11, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Daniel ZuckerAmiram Goldblum
Oct 6, 2009·Advanced Drug Delivery Reviews·Narayan BhattaraiMiqin Zhang
Jun 1, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jerzy GubernatorArkadiusz Kozubek
Aug 24, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Martin HossannLars H Lindner
Oct 1, 2010·Biomaterials·Chun-Ming HuangLiangfang Zhang
Oct 19, 2010·International Journal of Food Microbiology·Ming KongHyun Jin Park
Jun 8, 2011·International Journal of Pharmaceutics·Se-Jin ParkJeong-Sook Park
Jul 6, 2011·Drug Development and Industrial Pharmacy·Sohail AkhterFarhan J Ahmad
Aug 4, 2011·Expert Review of Anti-infective Therapy·Tianhong DaiMichael R Hamblin
Mar 6, 2012·International Journal of Pharmaceutics·Héloïse RagelleGuy G Chabot
Jun 12, 2012·International Journal of Pharmaceutics·Xiaoming XuDiane J Burgess
Jul 11, 2012·Journal of Pharmaceutical Sciences·Julia HurlerNataša Skalko-Basnet
Feb 5, 2013·International Journal of Nanomedicine·Ye JinWeiyu Zhang
Sep 3, 2013·International Journal of Pharmaceutics·Julia HurlerNataša Škalko-Basnet
Sep 4, 2013·International Journal of Pharmaceutics·Ayman Y WaddadJianping Zhou
Nov 13, 2013·Recent Patents on Anti-infective Drug Discovery·Mert SevgiMichael R Hamblin
May 6, 2014·Profiles of Drug Substances, Excipients, and Related Methodology·Mahmoud M H Al OmariAdnan A Badwan

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Citations

Dec 31, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Morteza AbazariYaser Maleki
May 22, 2019·Expert Opinion on Drug Delivery·Mrunal JadhavAbdelwahab Omri
Jun 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Banyi LuXiaoying Long
Dec 17, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Karolina MulasMarcin Sobczak
Nov 19, 2020·International Journal of Nanomedicine·Morteza YaghoobianSimin Dadashzadeh
Apr 12, 2021·Carbohydrate Polymers·Lisa Myrseth HemmingsenNataša Škalko-Basnet

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